摘要
目的探讨人类免疫缺陷病毒(HIV)阳性女性患者宫颈高危型人乳头病毒(HR-HPV)感染情况以及子宫颈细胞学筛查情况。方法选取2013年1月—2016年9月深圳市第三人民医院爱心门诊就诊的HIV阳性女性患者206例为观察组,另选同期妇科门诊行宫颈癌筛查的HIV阴性患者206例为对照组,对两组患者行宫颈HPV检测及子宫颈液基薄层细胞涂片检查(LCT),观察两组患者宫颈HR-HP感染情况及LCT异常情况,并对观察组患者免疫功能指标予以分析。结果观察组患者HR-HPV感染率为33.50%,同对照组16.50%对比,差异有统计学意义(P<0.05);观察组患者LCT阳性率为87.86%,同对照组49.51%比较,差异有统计学意义(P<0.05);观察组中,HR-HPV感染患者CD8^+细胞数与未感染者比较差异无统计学意义(P>0.05),CD4^+细胞数及CD4^+/CD8^+较未感染患者低,差异有统计学意义(P<0.05)。结论 HIV阳性女性HR-HPV感染概率较大,LCT阳性检出率更高,宫颈上皮病变及恶性病变发生风险较大;HIV阳性患者感染HR-HPV同CD4^+细胞数及CD4^+/CD8^+有一定关联。
objective To investigate the situations of high risk human papillomavirus（HR-HPV） infection in human immunodeficiency virus（HIV） positive female persons and cervical cytology screening. Methods A total of 206 cases of HIV positive female persons in our hospital outpatient service from January 2013 to September 2016 were selected as an observation group, and at the same time, 206 cases of HIV negative persons in our hospital gynecology clinic for cervical cancer screening were selected as a control group. HPV detection and cervical liquid based cytological thin smear technique（LCT） were performed in the persons of two groups. The HR-HPV infection and LCT abnormal persons in two groups were observed and the immune function indexes of the persons in the observation group were analyzed. Results The HR-HPV infection rate in the observation group was 33.50%, which was significantly higher than 16.50% in the control group and the difference was statistically significant（P〈0.05）. The LCT positive rate in the observation group was 87.86%, which was significantly higher than 49.51% in the control group and the difference was statistically significant（P〈0.05）. In the observation group, there was no significant difference in the number of CD8^＋ cells between HR-HPV infected persons and ones without infection（P〈0.05）.The number of CD4^＋ cells and the ratio of CD4^＋/CD8^＋ in the infected persons were significantly lower than those in the uninfected persons, and the difference was statistically significant（P〈0.05）. Conclusions The positive rate of HR-HPV infection is higher in the HIV positive women, the positive rate of LCT is higher, and the risks of cervical epithelial lesions and malignant lesions are higher. The HR-HPV infection rate of HIV positive persons is correlated with the number of CD4^＋ cells and the ratio of CD4^＋/CD8^＋.
作者
蔡秋娥
万建玉
王淼
陈丽云
CAI Qiue WAN Jianyu WANG Miao CHEN Liyun(Third People ＇s Hospital of Shenzhen City, Shenzhen, Guangdong 518000, China)
出处
《中国热带医学》
CAS
2017年第9期939-940,958,共3页
China Tropical Medicine
关键词
人类免疫缺陷病毒
高危型人乳头病毒
子宫颈细胞学筛查
宫颈癌
human immunodeficiency virus
high risk human papillomavirus
cervical cytology screening
cervical cancer
