摘要
自我国印发消除疟疾行动计划以来,对疟原虫溯源技术的需求日益迫切,该技术同样可以应用于药物抗性虫株起源的追溯及传播路径的监测,因此,选择简单、特异性的分子标记物用于疟原虫的溯源显得尤为重要。本文从疟原虫染色体的单核苷酸多态性、疟原虫微卫星片段长度多态性、疟原虫线粒体及顶质体的单核苷酸多态性等三方面对近年来应用于疟原虫溯源的方法及选择的分子标记进行综述。
Since the launch of the malaria elimination policy in China, there has been an increasing demand for malaria parasite traceability technology, which can also be applied to trace the origin and spread of drug resistant parasite strains.Therefore, simple and specific molecular markers are in great request to achieve this purpose. In this paper, we review the methods and molecular markers used to trace the source of malaria parasites from three aspects, the Single Nucleotide Polymorphisms of malaria parasite chromosome, microsatellite fragment length polymorphism of malaria parasite, Single Nucleotide Polymorphisms of malaria parasite mitochondria and top plastids.
作者
陈学迪
叶润
潘卫庆
CHEN Xuedi YE Run PAN Weiqing(Department of Tropical Infectious Diseases, The Second Military Medical University, Shanghai 200433, Chin)
出处
《中国热带医学》
CAS
2017年第9期947-949,共3页
China Tropical Medicine
基金
国家自然科学基金(No.81601780)
关键词
疟疾
溯源
抗药性
malaria
origion-traceing
drug resistance
