摘要
目的旨在建立广州北部妊娠期血清甲状腺功能指标的参考区间,并追踪探讨不同孕期孕妇甲状腺功能紊乱与不良妊娠结局的关系。方法选择2014年6月—2016年5月到该院产科门诊就诊的922名孕妇为观察对象,利用化学发光法检测孕妇孕早期、中期、晚期的甲状腺功能情况,建立该地区妊娠期特异的血清甲状腺功能指标的正常参考区间,并通过随访分析甲状腺功能正常者与异常者之间不良妊娠结局发生率的差异。结果 (1)血清TSH在孕早期、孕中期、孕晚期的参考范围分别为:0.04~4.86 mIU/L、0.09~5.77 mIU/L、0.24~6.89 mIU/L;(2)血清FT4在孕早期、孕中期、孕晚期的参考范围分别为:11.01~21.37 pmol/L、10.43~21.30 pmol/L、8.78~20.99 pmol/L;(3)甲亢组妊高征几率为25.00%、自然流产率12.50%、早产率25.00%、小于孕龄儿率12.50%、胎儿窘迫率25.00%、引产率12.50%,均显著高于甲状腺功能正常组(P<0.05);亚甲减组自然流产率4.76%、早产率28.57%、胎儿窘迫率9.52%,明显高于甲状腺功能正常组(P<0.05)。结论建立广州北部妊娠期血清甲状腺功能指标参考值,有助于临床医生快速、有效地确诊孕期甲状腺功能异常,及时采取有效干预措施,对改善不良妊娠结局、促进母婴健康具有较高的临床应用价值。
Objective To establish the reference range of specific serum thyroid function indexes during the gestational period in the northern Guangzhou and study the correlation between the thyroid function disorders of delivery women of different pregnant periods and adverse gestational outcome. Methods 922 cases of delivery women diagnosed in the clinic in our hospital from June 2014 to May 2016 were selected and the thyroid functions of delivery women during the early pregnancy, middle pregnancy and late pregnancy were tested by the chemiluminescent immunoassay, and the difference in the incidence rate of adverse pregnant outcomes between the people with normal and abnormal thyroid functions was analyzed by follow-up. Results The reference ranges of serum TSH in the early pregnancy, middle pregnancy and late pregnancy were respectively 0.04~4.86 mIU/L,0.09~5.77 mIU/L,0.24~6.89 mIU/L, and the reference ranges of serum FT4 in the early pregnancy, middle pregnancy and late pregnancy were respectively 11.01~21.37 pmol/L,10.43~21.30 pmol/L,8.78 ~20.99 pmol/L and the probability of pregnancy-induced hypertension syndrome, natural abortion rate, premature rate in the hyperthyroidism group were lower than the gestational age infant rate, fetal distress rate and induced labor rate（25.00%, 12.50%, 25.00% vs 12.50%, 25.00%,12.50%）and those in the normal thyroid function group（P〈0.05）, and the natural labor rate, premature rate and fetal distress rate in the sub-hypothyroidism group were respectively 4.76%, 28.57% and 9.52%, which were obviously higher than those in the normal thyroid function group（P〈0.05）. Conclusion The establishment of specific serum thyroid function indexes during the gestational period in the northern Guangzhou contributes to the rapid and effectively diagnosis of thyroid function abnormalities of clinical doctors, and the timely use of effective intervention measures is of higher clinical application value to improving the adverse pregnant outcomes and promoting the maternal and infant health.
出处
《系统医学》
2017年第11期97-99,共3页
Systems Medicine
关键词
广州北部
妊娠
甲状腺功能
妊娠结局
Northern Guangzhou
Pregnancy
Thyroid function
Gestational outcome
