摘要
目的分析真实世界的复方苦参注射液治疗白血病的临床用药特征。方法提取全国22家三甲医院信息系统(HIS)数据库中使用复方苦参注射液治疗白血病患者的基本信息、中西医诊断信息、医嘱信息、实验室检查信息,采用Apriori算法建立模型,使用Clementine12.0进行关联分析,对真实世界中复方苦参注射液治疗白血病的临床用药特征进行观察。结果复方苦参注射液与西药联用时,联合用药频次最高的为碳酸氢钠片占77.96%,联合西药药理作用最高的为抗肿瘤化疗药占85.90%,联合两种西药最高的为地塞米松+碳酸氢钠片(关联规则支持度为65.4%),联合两种西药药理作用最高的是抗肿瘤化疗药+抗生素类药(关联规则支持度是75.6%),与阿糖胞苷注射液、地塞米松、碳酸氢钠片联合用药频率均≥47.9%,中西药物联合用药时复方苦参注射液+抗肿瘤化疗药+抗生素类药物,复方苦参注射液+抗肿瘤化疗药+糖皮质激素,复方苦参注射液+抗肿瘤化疗药+清热解毒剂的频率均≥52.7%。结论复方苦参注射液在临床上与西医的化疗方案联合用药多见。
Objective To analyze the characteristics of clinical medication of fufang kushen injection for leukemia in the real world. Methods The basic information,diagnostic information of Chinese and western medicine,physical advice information and laboratory examination information for the treatment of leukemia with fufang kushen injection were collected from the database of 22 hospital information systems in China. Apriori algorithm was adopted for model construction. Clementine 12. 0 was used for association analysis. The clinical medication characteristics were observed in the treatment of leukemia with fufang kushen injection in the real world. Results For the combined medication of fufang kushen injection with western medicines,the combined western medicine of the highest frequency was sodium bicarbonate tablets,accounting for77. 96%. The combined western medicine of the highest pharmaceutical effect was chemotherapeutic drugs for antitumor,accounting for 85. 90%. The the combination of two western drugs with the highest frequency was dexamethasone ＋ sodium bicarbonate tablets（ the association rule support degree was 65. 4%）. The combinationof two western drugs with the highest pharmaceutical effect was antitumor chemotherapeutic agents and antibiotics（ the association rule support degree was 75. 6%） and the the frequency of combined medication with cytarabine injection,dexamethasone and sodium bicarbonate tablets was≥47. 9%. In the combination of western agents and Chinese medicines,the frequency of fufang kushen injection ＋ antitumor chemotherapeutic agents＋ antibiotics,that of fufang kushen injection ＋ antitumor chemotherapeutic agents ＋ glucocorticoid,and that of fufang kushen injection ＋ antitumor chemotherapeutic agents ＋ the agents for clearing heat and detoxification were all≥52. 7%. Conclusion Fufang kushen injection is the common drug in combination with chemotherapy of western medicine in clinical practice.
出处
《世界中西医结合杂志》
2017年第8期1048-1052,1068,共6页
World Journal of Integrated Traditional and Western Medicine
基金
国家重大新药创制科技重大专项(2015ZX09501004-001-002)
北京市中医药科技发展专项(JJ2014-53)
中国中医科学院自主选题项目(PY1303)
关键词
复方苦参注射液
白血病
联合用药
医院信息系统
Fufang Kushen Injection
Leukemia
Drug Combination
Hospital Information System
