摘要
目的探讨患者院前急救中选择胺碘酮与盐酸普罗帕酮治疗阵发性室上性心动过速的临床疗效。方法 89例本院急救中心急救阵发性室上性心动过速患者,随机分为盐酸普罗帕酮组(43例)与胺碘酮组(46例),两组各自运用相关药物治疗,观察比较两组患者转复时间、转复效果及不良反应发生情况。结果盐酸普罗帕酮组患者平均转复时间(13.3±3.1)min明显短于胺碘酮组(25.1±5.2)min,差异具有统计学意义(P<0.05);两组转复时间分布比较差异具有统计学意义(P<0.05)。胺碘酮组的转复有效率91.30%高于盐酸普罗帕酮组的88.37%,但差异无统计学意义(P>0.05)。胺碘酮组不良反应发生率4.35%低于盐酸普罗帕酮组18.60%,差异具有统计学意义(P<0.05)。结论阵发性室上性心动过速患者选择胺碘酮与盐酸普罗帕酮两种药物治疗均能获得显著治疗效果,胺碘酮的疗效较盐酸普罗帕酮疗效稍好,而且不良反应发生率低,但是病症转复时间比较长。
Objective To investigate the clinical efficacy of amiodarone and propafenone hydrochloride for the treatment of paroxysmal supraventricular tachycardia in prehospital first aid. Methods A total of 89 patients with paroxysmal supraventricular tachycardia in prehospital first aid were randomly divided into propafenone hydrochloride group （43 cases） and amiodarone group （46 cases）. Both groups were treated with related drugs, and observation and comparison were made on recovery time, effective recovery rate and occurrence of adverse reactions in two groups. Results The propafenone hydrochlorlde group had obviously shorter mean recovery time as （13.3 ＋ 3.1） min than （25.1 ＋ 5.2） min in amiodarone group, and the difference was statistically significant （P〈0.05）. Both groups bad statistically significant difference in recovery time distribution （P〈0.05）. The amiodarone group had higher effective recovery rate as 91.30% than 88.37% in propafenone hydrochloride group, but the difference was not statistically significant （P〉0.05）. The amiodarone group had lower incidence of adverse reactions as 4.35% than 18.60% in propafenone hydrochloride group, and the difference was statistically significant （P〈O.05）. Conclusion Both amiodarone and propafenone hydrochloride provides remarkable treatment effect for patients with paroxysmal supraventricular tachycardia. The efficacy of amiodarone is better than that of propafenone hydrochlofide, and the incidence of adverse reactions is low, but the disease recovery time is relatively long.
作者
张瑞兰
张喜俊
郭莉娟
李凌云
ZHANG Rui-lan ZHANG Xi-jun GUO Li-juan et al(Emergency Center, Xinjiang Yili Friendship Hospital, Yining 835000, Chin)
出处
《中国实用医药》
2017年第27期104-106,共3页
China Practical Medicine
关键词
胺碘酮
盐酸普罗帕酮
阵发性室上性心动过速
治疗效果
Amiodarone
Propafenone hydroch/oride
Paroxysmal supraventricular tachycardia
Treatment effect
