摘要
目的:探讨天麻素联合卡马西平治疗脑梗死后继发癫痫的临床疗效。方法:选取2011年4月—2016年9月该院收治的脑梗死后继发癫痫的患者86例为研究对象,采用随机数字表法分为治疗组与对照组,对照组患者给予卡马西平治疗,治疗组患者给予天麻素联合卡马西平治疗的基础上加用中医辨证治疗,对比两组患者的临床疗效、脑电图改善情况,在治疗前后检测患者白细胞介素-1β(IL-1β)、D-二聚体(D-D)及肿瘤坏死因子-α(TNF-α)的水平变化,并观察两组患者不良反应发生情况。结果:治疗组与对照组的总有效率分别为93.02%、76.74%,两组相比,治疗组总有效率明显升高(P<0.05);治疗组与对照组脑电图改善率分别为90.70%、81.39%,两组相比,治疗组脑电图改善率明显升高(P<0.05);与治疗前对比,治疗后治疗组与对照组患者的IL-1β、D-D、TNF-α水平均明显降低(P<0.05),且治疗组患者IL-1β、D-D、TNF-α水平改善程度优于对照组(P<0.05);治疗组与对照组的不良反应发生率分别11.63%、13.95%,两组不良反应发生率对比无显著差异(P>0.05)。结论:天麻素联合卡西马平治疗的基础上加用中医辨证治疗脑梗后继发癫痫可显著提高临床疗效,改善脑电图状况,值得推广应用。
Objective： To analyze the clinical curative effect of gastrodin combined with carbamazepine in the treatment of secondary epilepsy after cerebral infarction. Methods： During April 2011-September 2016 in our hospital,86 cases of secondary epilepsy after cerebral infarction patients were as the research objects. By using the random number table method,they were divided into the treatment group and control group. The control group patients were given carbamazepine treatment and the patients in the treatment group were treated with gastrodin combined with carbamazepine and TCM syndrome differentiation. We compared two groups＇ clinical curative effect. Before and after treatment,patients＇ abnormal EEG,interleukin 1 beta（ IL-1 beta）,D-dimer（ D-D） and tumor necrosis factor alpha（ TNF alpha） level changes were tested and we observed the adverse reactions occurred in both groups. Results： Treatment group and control group＇ s total effective rates were 93. 02% and 76. 74% respectively. The treatment group＇s total effective rate increased significantly（ P〈0. 05）. The treatment group and control group＇ s EEG improved rates were 90. 70%,81. 39%. The treatment group＇ s was obviously increased（ P〈0. 05）. Compared with before treatment,the treatment group and control group＇s IL-1 beta,D-D and TNF alpha levels were significantly lower（ P〈0. 05） and the treatment group patients＇ IL-1 beta,D-D and TNF alpha levels improvement were better than those of control group（ P〈0. 05）.The treatment group and control group＇s incidence was 11. 63% and 13. 95% respectively,and the incidence of the two groups had no significant difference（ P〈0. 05）. Conclusion： The combination of gastrodin combined with carbamazepine in the treatment of epilepsy after cerebral infarction can significantly improve the clinical efficacy with TCM and EEG,worthy of popularization and application.
出处
《辽宁中医杂志》
CAS
北大核心
2017年第9期1924-1926,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
云南省卫生科技计划项目(2016NS223)
关键词
天麻素
卡马西平
脑梗死后继发癫痫
临床疗效
gastrodin
carbamazepine
secondary epilepsy after cerebral infarction
clinical effect
