摘要
目的探讨2型糖尿病合并Hp感染胃溃疡患者外周血中T淋巴细胞亚群的变化及其临床意义。方法选取45例2型糖尿病合并Hp感染的胃溃疡组作为研究对象(DM组),同期住院的50例不伴有2型糖尿病仅存在Hp感染的胃溃疡组作为对照组,采用流式细胞仪免疫荧光法检测两组T淋巴细胞亚群的百分数并对结果进行统计学分析,并观察两组患者白介素-17(IL-17)以及C-反应蛋白水平(CRP)。结果 DM组和对照组CD4^+和CD4^+/CD8^+的测定结果相比较,差异均有统计学意义,DM组的CD4~^+呈显著负相关(P<0.01),CD4^+/CD8^+呈显著负相关(P<0.05)。DM组患者IL-17、CRP水平明显高于对照组。结论 2型糖尿病合并Hp感染的胃溃疡患者存在细胞免疫功能紊乱,提示与Hp感染相关。
Objective To explore the change and clinical significance of T lymphocyte subsets in peripheral blood of patients with type 2 diabetes mellitus complicated with Hp infection with gastric ulcer. Methods 45 patients with type 2 diabetes mellitus complicated with Hp infection were selected as gastric ulcer group. During the same period, 50 patients without type 2 diabetes mellitus with only Hp infection were enrolled as control group. The percentage of T lymphocyte subsets in two groups was detected by flow cytometry and immunofluorescence analysis. The results were statistically analyzed. The levels of interleukin -17 （IL-17） and C- reactive protein （CRP） were observed in the two groups. Results The results of CD4^＋ and CD4^＋/CD8^＋ in the DM group and the control group were compared, the differences were statistically significant. The CD4^＋ in DM group was negatively correlated （P 〈 0.01）. There was a negative correlation between CD4^＋/CD8^＋ （P 〈 0.05）. The levels of IL-17 and CLIP in patients in group DM were significantly higher than those in control group. Conclusion There is a disorder of cellular immunity in patients with type 2 diabetes mellitus complicated with Hp infection, which suggests that it is associated with Hp infection.
出处
《中国医药科学》
2017年第17期227-229,共3页
China Medicine And Pharmacy
关键词
2型糖尿病
HP感染
胃溃疡
T淋巴细胞亚群
Type 2 diabetes mellitus
Hp infection
Gastric ulcer
T lymphocyte subsets
