乌司他丁联合抗感染治疗对急性重症肺炎患者全身炎症、氧化应激反应的影响被引量：29

Effect of ulinastatin combined with anti-infective therapy on systemic inflammatory response and oxidative stress response in patients with acute severe pneumonia

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摘要目的:探讨乌司他丁联合抗感染治疗对急性重症肺炎患者全身炎症、氧化应激反应的影响。方法:收集在本院接受治疗的急性重症肺炎患者50例,随机分为对照组、观察组各25例。对照组接受常规治疗,观察组接受乌司他丁联合常规治疗。治疗前及治疗后10天时,测定血清中炎症反应、氧化应激反应的差异。结果:治疗前,两组血清中炎症反应指标、氧化应激指标含量的差异无统计学意义(P<0.05)。治疗后,两组血清中IL-2、IL-6、PCT、HMGB1、CRP、IL-4、IL-10、IL-13、MDA、AOPP、ROS的含量均低于治疗前,SOD、T-AOC、GSH-Px、LHP的含量高于治疗前,且观察组血清中IL-2、IL-6、PCT、HMGB1、CRP、IL-4、IL-10、IL-13、MDA、AOPP、ROS的含量均低于对照组,SOD、T-AOC、GSH-Px、LHP的含量高于对照组(P<0.05)。结论:急性重症肺炎患者接受乌司他丁联合抗感染治疗,可有效降低全身炎症反应及氧化应激反应,优化整体病情。 Objective：To study the effect of ulinastatin combined with anti-infective therapy on systemic inflammatory response and oxidative stress response in patients with acute severe pneumonia.Methods：A total of 50 patients with acute severe pneumonia who were treated in the hospital were collected and divided into control group and observation group according to the random number table method,25 cases in each group.Control group received conventional therapy,and the observation group received ulinastatin combined with conventional therapy.The differences in inflammatory response and oxidative stress response in serum were measured before treatment and 10 days after treatment.Results：Before treatment,differences in serum levels of inflammatory response indexes and oxidative stress indexes were not statistically significant between the two groups（P〈0.05）.After treatment,serum IL-2,IL-6,PCT,HMGB1,CRP,IL-4,IL-10,IL-13,MDA,AOPP and ROS levels of both groups of patients were lower than those before treatment,while SOD,T-AOC,GSH-Px and LHP levels were higher than those before treatment,and serum IL-2,IL-6,PCT,HMGB1,CRP,IL-4,IL-10,IL-13,MDA,AOPP and ROS levels of observation group were lower than those of control group,while SOD,T-AOC,GSH-Px and LHP levels were higher than those of control group（P〈0.05）.Conclusion：Ulinastatin combined with anti-infective therapy can effectively reduce the systemic inflammatory response and oxidative stress response,and optimize the overall condition in patients with acute severe pneumonia.

作者彭洁安娜马骏麒

机构地区新疆医科大学附属中医医院急诊科

出处《海南医学院学报》 CAS 2017年第16期2180-2183,共4页 Journal of Hainan Medical University

基金新疆维吾尔自治区中医民族医药管理局项目(20160402)~~

关键词急性重症肺炎乌司他丁炎症反应氧化应激 Acute severe pneumonia Ulinastatin Inflammatory response Oxidative stress

分类号 R563.1 [医药卫生—呼吸系统]