摘要
目的:研究加味四逆散治疗腹泻型(肝郁脾虚型)肠易激综合征的疗效。方法:将120例腹泻型肠易激综合征患者按照1∶1原则分为治疗组60例和对照组60例,治疗组用加味四逆散治疗,对照组用匹维溴铵治疗,疗程均为6周。治疗前后对患者进行主要症状量化评分、IBS-QOL量表维度积分评分和治疗效果评价。结果:治疗后两组主要临床症状量化得分均下降,差异均有统计学意义(P<0.05),治疗组量化得分低于对照组,差异有统计学意义(P<0.05);两组IBS-QOL积分及总分均提高,差异均有统计学意义(P<0.05);治疗组治疗后健康忧虑积分和总分均高于对照组,差异有统计学意义(P<0.05)。治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后两组血清IL-1β和IL-8水平均降低,差异均有统计学意义(P<0.05);治疗组治疗后血清IL-1β和IL-8水平低于对照组,差异均有统计学意义(P<0.05)。结论:加味四逆散治疗腹泻型肠易激综合征(肝郁脾虚型)疗效显著。
Objective： To observe the effect of Jiawei Sini San （加味四逆散, JWSNS） on diarrhea type of irritable bowel syndrome. Methods： The 120 patients with irritable bowel syndrome were randomly divided into treatment group and control group, 60 cases in each. The treatment group was given JWSNS, while the control group was treated with pinaverium bromide, treatment for 6 weeks. Before and after treatment, the main symptom scores, IBS-QOL scale scores and therapeutic effect were evaluated. Results： After treatment, the main clinical symptoms scores in treatment group and control group decreased, the difference was statistically significant （P〈0.05）, the scores of treatment group were lower than the control group, the difference was statistically significant （P〈0.05）; the IBS-QOL scores and the total scores of the treatment group and the control group were improved, the difference was statistically significant （P〈0.05）; and the treatment group after treatment of integral health concerns and the total score were higher than the control group, the difference was statistically signifi- cant （P〈0.05）. Compared with the control group, the treatment group had higher total effective rate, and the difference was statistically significant （P〈0.05）. After treatment, the treatment group and the control group of serum IL-1β and IL-8 level was lower than that before treatment, the difference was statistically significant （P〈0.05）; serum IL-1β and IL-8 level of treatment group was lower than the treatment group, the difference was statistically significant （P〈0.05）. Conclusion： JWSNS has a significant clinical effect in the treatment of diarrhea predominant irritable bowel syndrome （liver stagnation and spleen deficiency type）.
出处
《中医药导报》
2017年第18期73-76,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
河北省中医药管理局科研计划项目(2016272)
关键词
肠易激综合征
腹泻型
肝郁脾虚型
加味四逆散
irritable bowel syndrome
diarrhea type
liver stagnation with spleen deficiency
Jiawei Sini San
