摘要
目的:观察益肾活血方对慢性肾脏病CKD3-4期血瘀证患者临床疗效、炎症细胞因子以及血管内皮功能的影响。方法:将86例CKD3-4期患者随机抽样法分为西药常规治疗组(对照组)、益肾活血方+西药常规治疗组(治疗组),每组各43例,检测患者治疗前后血清Scr、BUN、GFR、TNF-α、IL-6水平和VWF:Ag、ADAMTS13活性。结果:益肾活血方治疗组一方面能明显改善CKD3-4期血瘀证患者的临床症状,降低Scr、BUN水平,升高GFR;另一方面,益肾活血方还能明显降低患者血清TNF-ɑ、IL-6炎症因子水平及VWF活性,增加ADAMTS13活性。结论:益肾活血方能显著改善CKD3-4血瘀证患者临床症状,提高肾功能,降低炎症因子和减轻血管内皮损伤。
Objective： To observe the effect of Yishen Huoxue Prescription on clinical effects, inflammatory cytokines and vascular endothelial function levels of patients with blood stasis syndrome on CKD3 - 4 stage. Method： Eighty - six CKD3 -4 patients were randomly divided into Western medicine routine treatment group （control group）, Yishen Huoxue prescription ＋ conventional Western medicine treatment group （treatment group）. Forty -three cases on each group were tested before and after treatment in patients with serum levels of Scr, BUN and GFR, levels of TNF alpha, IL - 6 and VWF： Ag, ADAMTS13 activity. Result：Yishen Huoxue Prescription ＋ conventional Western medicine treatment can obviously improve the CKD3 -4 clinical symptoms of patients with blood stasis, lower levels of Scr and BUN and higher GFR. On the other hand, it also can significantly reduce serum TNF - α, IL - 6, inflammatory factor levels and VWF activity and increase ADAMTS13 activity. Conclusion：Yishen Huoxue Prescription can significantly improve clinical symptoms in patients with blood stasis syndrome CKD3 -4 and renal function and reduce inflammation factors and vascular endothelial damage.
出处
《中华中医药学刊》
CAS
北大核心
2017年第10期2508-2511,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81360536
81760807)
广西自然科学基金面上项目(2016GXNSFAA380047)
关键词
慢性肾脏病
血瘀证
益肾活血方
炎症因子
血管内皮
chronic kidney disease
syndrome of blood stasis
Yishen Huoxue Prescription
inflammatory factor
blood vessel endothelium
