摘要
目的探讨帕罗西汀联合疏肝解郁胶囊对女性抑郁症伴焦虑症状患者疗效观察。方法将64例女性抑郁症伴焦虑症状者随机分2组各32例,联合组予帕罗西汀联合疏肝解郁胶囊,对照组予帕罗西汀,疗程均6周,采用汉密尔顿抑郁量表HAMD和汉密尔顿焦虑量表HAMA评定疗效,并记录不良反应情况。结果联合组总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗后HAMD、HAMA评分较治疗前均明显降低,差异均有统计学意义(P<0.05),联合组在治疗后1周、2周的HAMD、HAMA与对照组比较,差异就有统计学意义(P<0.05)。且联合组加用舒肝解郁胶囊后无明显增加不良反应。结论帕罗西汀联合疏肝解郁胶囊治疗女性抑郁症伴焦虑症状患者具有协同作用,不但起效快,而且无明显增加不良反应。
OBJECTIVE To investigate the Paroxetine combined with Shuganjieyu Capsule on female patients with depression with anxiety symptoms. METHODS 64 cases of female depression with anxiety symptoms were ran- domly divided into 2 groups of 32 cases, combined group treated with Paroxetine combined with Shuganjieyu capsule, the control group received Paroxetine, 6 weeks of treatment, Using Hamilton depression scale HAMD and Hamilton anxiety scale and HAMA to assess the efficacy and the side effects were recorded. RESULTS The total effective rate of the combined group was higher than that of the control group,the difference was statistically significant（ P 〈 0. 05 ）. The two groups after treatment HAMD and HAMA score, were significantly lower than before treatment, the differences were statistically significant （P 〈 0. 05 ）, combination group in 1 weeks and 2 weeks after treatment, com- pared with the control group, the difference of HAMD, HAMA scores was statistically significant （ P 〈 0. 05 ）. And the United Group with no significant increase in adverse reactions after using Shugan Jieyu capsule. CONCLUSION Paroxetine combined with Shuganjieyu capsule in the treatment of female depression has a synergistic effect in pa- tients with anxiety symptoms, not only fast, but also no significant increase in adverse reactions.
出处
《海峡药学》
2017年第9期75-77,共3页
Strait Pharmaceutical Journal
