摘要
目的研究冻干人用狂犬病疫苗(地鼠肾细胞)有无过敏反应。方法采用豚鼠主动全身过敏试验、小鼠腘窝淋巴结试验和大鼠被动皮肤过敏试验,全面评价冻干人用狂犬病疫苗肌肉注射能否引起过敏反应。结果冻干人用狂犬病疫苗豚鼠主动全身过敏试验出现弱阳性反应;小鼠腘窝淋巴结试验结果为阳性,大鼠被动皮肤过敏试验出现潜在的阳性反应。结论冻干人用狂犬病疫苗肌肉给药可能引起过敏反应,临床应用需密切关注。
Objective To study the anaphylaxis of freeze-dried rabies vaccine （hamster kidney cell） for human use. Methods The anaphylaxis of freeze-dried rabies vaccine for human use was evaluated with three tests including active systemic anaphylaxis （ASA） in guinea pigs, popliteal lymph node assay （PLNA） in BALB/c mice and passive cutaneous anaphylaxis （PCA） in rats. Results The result of popliteal lymph node assay （PLNA） is positive; weakly positive result of ASA in guinea pigs was observed; potentially positive reactions of PCA in rats were also observed. Conclusion There are potentially allergic reactions when freeze-dried rabies vaccine （hamster kidney cell） for human were injected intramuscularly.
作者
马玉奎
高梅
贾庆文
MA Yu-kui GAO Mei JIA Qing-wen(Shandong Academy of Pharmaceutical Sciences, Jinan 250100, China)
出处
《食品与药品》
CAS
2017年第5期310-313,共4页
Food and Drug
基金
山东省创新公共服务平台项目(2015CXPT00001)
关键词
冻干人用狂犬病疫苗
主动全身过敏
胭窝淋巴结试验
被动皮肤过敏
freeze-dried rabies vaccine （hamster kidney cell） for human use
active systemic anaphylaxis
popliteal lymph node assay
passive cutaneous anaphylaxis
