摘要
蒺藜水提取物对迟发型变态反应影响的研究表明,结果发现,蒺藜明显抑制2,4,6-三硝基氯苯(PC)及2,4-二硝基氯苯(DNCB)所致的接触性皮炎和绵羊红细胞(SRBC)所致的足跖反应。对PC所致迟发型变态反应(PC-DTH)的效应期无影响;对用环磷酰胺(Cy)前处理而增强的PC-DTH,蒺藜致敏后给药有明显的抑制作用,而致敏前给药则无作用;但对未用Cy处理的小鼠,致敏前给予蒺藜则抑制了PC-DTH。此外,蒺藜对二甲苯以及巴豆油引起的小鼠耳壳炎症反应均无影响。以上结果表明,蒺藜水提取物对迟发型变态反应的抑制作用主要是通对抑制诱导期中的效应细胞(T_(DTH))的分化与形成。
The effect of aqueous extract of Fructus Tribuli (FT) on delayed type hypersensitivity (DTH) and its mechanisms were studied. FT markedly inhibited 2 kinds of contact dermatitis induced by picryl chloride (PC) and dinitrochlorobenzene (DNCB), and also showed a significant inhibition of footpad reaction induced by sheep red blood cells (SRBC). To the induction phase of PC-induced DTH (PC-DTH), FT significantly suppressed the primary immune response, and slightly showed a tendency to inhibit the secondary immune response. However, the drug showed no effect on the effector phase of PC-DTH. The pretreatment with cyclophosphamide (Cy) before PC sensitization remarkably augmented PC-DTH. An administration of FT after PC sensitization significantly lowered the augmented PC-DTH, while no influence was observed when given before sensitization. But the administration of FT before sensitization to the Cy-non-treated mice depressed PC-DTH clearly. On the other hand, FT did not show any antiinflammatory acitivity against xylene- and croton oil-induced ear edema. These results suggest that FT possesses the anti-DTH activity mainly through inhibiting the differentiation and formation of effector cell (T_(DTH)) in induction phase of DTH.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1991年第1期12-16,共5页
Journal of China Pharmaceutical University
关键词
蒺藜
变态反应
抑制作用
Fructus Tribuli
Tribulus terrestris L.
Delayed type hypersensitivity
Contact dermatitis
