摘要
目的探讨慢性乙型肝炎(CHB)患者血清中还原型谷胱甘肽(GSH)水平变化,评价临床上应用GSH治疗CHB的效果。方法选取44例CHB患者(CHB组),其中谷丙转氨酶(ALT)水平升高34例,正常10例。ALT水平升高34例患者中,HBV-DNA阳性11例,阴性12例;HBe Ag阳性12例,阴性11例。将ALT水平升高的34例CHB患者随机分为GSH治疗组和无GSH治疗组各17例,GSH治疗组综合治疗基础上加用GSH注射液治疗4周。治疗前及治疗4周后采用全自动生化分析仪检测患者血清ALT、谷草转氨酶(AST)、总胆红素(TBIL)、白蛋白(ALB)水平,采用多功能酶标仪检测血清GSH水平。另外选取20例体检健康者作为对照组。结果 CHB组血清GSH水平低于对照组(P<0.05);ALT升高CHB患者血清GSH水平低于ALT正常者(P<0.05);HBV-DNA阳性与阴性、HBe Ag阳性与阴性患者之间血清GSH水平比较无统计学差异(P均>0.05)。GSH治疗后,GSH治疗组血清ALT、AST、TBIL水平低于无GSH治疗组,ALB水平高于无GSH治疗组(P均<0.05)。CHB患者血清GSH水平与ALT水平呈负相关(r=-0.897,P<0.05)。结论 CHB患者血清GSH水平降低,GSH注射液治疗可改善CHB患者的肝功能。
Objective To investigate the changes in levels of reduced glutathione（ GSH） in serum of patients with chronic hepatitis B（ CHB） and to evaluate the effect of GSH on CHB. Methods We selected 44 patients with CHB（ CHB group）,including 34 cases with elevated ALT and 10 cases with normal ALT. Among 34 CHB patients with elevated ALT,11 cases were HBV-DNA positive and 12 were negative,12 were HBe Ag positive and 11 were HBe Ag negative. Thirty-four CHB patients with elevated ALT were randomly divided into the GSH treatment group and non-GSH treatment group with 17 in each. Patients in the GSH treatment group were treated with GSH injection for 4 weeks on the basis of comprehensive treatment. Before and after four-week treatment,we used the automatic biochemical analyzer to test the serum levels of alanine aminotransferase（ ALT）,aspertate aminotransferase（ AST）,total bilirubin（ TBil）,and albumin（ ALB）,and used the multimode reader to detect the serum level of GSH. In addition,20 healthy people were selected as the control group. Results The serum GSH level in the CHB group was lower than that in the control group（ P〈0. 05）. The serum GSH level of CHB patients with elevated ALT was lower than that in patients with normal ALT（ P〈0. 05）. The difference in the serum GSH between HBV-DNA positive and negative,between HBe Ag positive and negative patients was not statistically significant（ P〉0. 05）. After treatment with GSH,the serum levels of ALT,AST,and DBIL were lower,but ALB level was higher in the GSH treatment group than those of the non-GSH treatment group（ all P〈0. 05）. Serum GSH level in CHB patients was negatively correlated with ALT level（ r =-0. 897,P〈0. 05）. Conclusion Serum GSH level of CHB patients decreases,and GSH injection could improve the liver function of CHB patients.
作者
姜荷
李群
张国旗
盛楠
JIANG He LI Qun ZHANG Guoqi SHENG Nan(Weifang Medical University, Weifang 261053, China)
出处
《山东医药》
CAS
北大核心
2017年第33期23-25,共3页
Shandong Medical Journal
