摘要
目的探究睡眠质量对帕金森病患者视幻觉的影响，为临床降低帕金森病患者视幻觉提供依据。方法选取2015年1月～2016年1月于我院接受治疗的142例帕金森病患者为研究对象，其中31例并发视幻觉的患者为观察组，其余101例患者为对照组。采用帕金森病常规非运动并发症问卷（NMSquest）、帕金森病评定量表（UPDRS）评定两组患者帕金森病情发作程度；采用帕金森睡眠量表（PDSS）、匹兹堡睡眠治疗指数量表（PSQI）、爱泼沃期思睡量表（ESS）评价两组患者睡眠质量；比较两组患者睡眠时间、睡眠效率、睡眠紊乱发生率、生动梦境发生率、快速动眼睡眠期行为障碍（RBD）发生率；采用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、蒙特利尔认知评估量表（Mo—CA）、疲劳量表（FS-14）对患者进行评价；比较两组患者Hohen—Yahr分期、左旋多巴等效剂量、PD用药种类以及炎症因子的含量。利用logistics多因素回归分析对两组患者比较中具有统计学差异的项目进行回归分析，研究睡眠质量对帕金森病患者视幻觉的影响。结果两组患者帕金森病情发作程度无统计学差异；观察组PDSS得分76．41±16．84、PSQI得分10．17±2．42、ESS得分11．41±1．90，对照组PDSS得分92．48±22．13、PSQI得分6．72±1．87、ESS得分5．74±1．01；两组患者睡眠时间、睡眠效率、睡眠紊乱发生率、生动梦境发生率、RBD发生率均存在统计学差异（P〈0．05）；观察组HAMD得分82．14±4．67、HAMA得分86．11±5．14、MoCA得分25．84±10．12、FS-14得分82．17±6．58，对照组HAMD得分74．52±6．01、HAMA得分76．82±5．82、MoCA得分27．42±9．87、FS-14得分76．31±6．74；两组患者H—Y分期、左旋多巴等效剂量以及炎症因子的含量均有统计学差异。Logistics多因素回归分析结果显示睡眠障碍是帕金森病患者产生视幻觉的独立危险因素。结论睡眠障碍能够影响帕金森病患者视幻觉的发生，是产生视幻觉的独立危险因素。
Objective To explore the effect of sleep on the visual hallucinations in the patients with Parkinson disease （PD）. Methods 104 patients with PD in our hospital from January in 2015 to January in 2016 were selected. Among them 31 patients with visual hallucinations were the observation group and 101 patients were the control group. The routine non motor complications questionnaire （NMSquest） and Parkinson＇ s Disease Rating Scale （VPDRS） were used to assess the severity of PD in the two groups. The Parkinson＇ s amount of sleep table （PDSS）, Pittsburgh sleep therapeutic index scale （PSQI） and Aipowo period think sleep scale （ESS） were used to assess sleep quality in the two groups. Sleep time, sleep efficiency, sleep disorder rate, vivid dreams incidence and REM sleep behavior disorder （RBD） incidence in the two groups were compared. The Hamilton Depression Scale （HAMD） , Hamilton Anxiety Scale （HAMA）, Montreal cognitive assessment scale （MoCA） and fatigue scale （FS- 14） were used to evaluate the patients. Hohen - Yahr stage, levodopa equivalent dose medication, PD drugs and the content of inflammatory cytokines in the two groups were compared. The effect of sleep on visual hallucinations in the patients with PD in the two groups was analyzed by logistics multiple regression analysis. Results There was no statistical difference in the degree of PD in the two groups. In the observation group PDSS score was 76.41± 16. 84, PSQI score was 10. 17 ±2. 42 and ESS score wasll. 41 ± 1.90. In the control group PDSS score was 92. 48±22. 13, PSQI score was 6. 72 ± 1.87 and ESS score was 5.74± 1.01. There were statistically significant difference in sleep time, sleep efficiency, sleep disorder incidence rate, the occurrence rate of vivid dreams and RBD incidence in the two groups （P 〈 0. 05 ）. In the observation group the score of HAMD was 82. 14 ±4. 67, HAMA score was 86. 11 ±5.14, MOCA score was 24. 84 ±10. 12 and fs - 14 score was 82. 17 ± 6. 58. In the control group the score of HAMD was 74. 52 ± 6. 01, HAMA score was 76. 82 ±5.82, MOCA score was 27.42 ±9.87 and fs - 14 score was 76. 31 ±6. 74. There were statistically difference in H - Y stage, levodopa equivalent dose and the content of inflammatory factors in the two groups （P 〈 0. 05）. Logistics multiple regression analysis showed that sleep disorder was an independent risk factor of visual hallucinations in the patients with PD. Conclusion Sleep disorders can affect the occurrence of visual hallucinations in the patients with PD, which is an independent risk factor of visual hallucinations.
作者
童琳
于海燕
Tong Lin Yu Haiyan(Department of Neurology, Yantai Hospital, Binzhou Medical College, Yantai 264100, China)
出处
《国际老年医学杂志》
2017年第5期193-196,共4页
International Journal of Geriatrics
基金
国家自然科学基金（30770768）
关键词
睡眠质量
帕金森病患者
视幻觉
Sleep status
Parkinson disease
Visual hallucinations
