摘要
目的探讨非老年2型糖尿病患者中OSAHS与25羟维生素D3[25（OH）D3]水平的关系。方法根据睡眠呼吸暂停指数（AHI），将158例2型糖尿病患者分为单纯糖尿病组（T2DM组38例）、OSAHS轻度组（OM_A组38例）、中度组（OM-B组46例）及重度组（OM-C组36例），比较各组间临床资料及25（OH）D3等指标的差异及相关性。结果T2DM组的HOMA-IR显著低于OM-B组和OM-C组，差异有统计学意义（F=18．24，P〈O．05）。OM-C组与T2DM组在TG的差异有统计学意义（F=40．18，P〈O．05）。4组间在2hPG、25（OH）D3及SaO2min的差异有统计学意义（F=29．54、32．16、24，27，P〈0．05）。相关分析提示25（OH）D3水平与AHI、2hPG呈负相关（P〈O．05），与Sa02min呈正相关（P〈0．05）。结论2型糖尿病患者25（OH）D3水平与0SAHS有显著相关性。
Objective Discuss the association between 25 hydroxy vitamin D3 [25（OH）D3] and obstructive sleep apnea hypopnea syndrome （OSAHS） in non-elderly patients with type 2 diabetes. Methods According to the level of AHI, 158 patients with type 2 diabetes were divided into four groups： the simple diabetes group （T2DM group, 38 cases）, OSAHS mild group （OM-A group, 38 cases）, OSAHS moderate group （OM-B group, 46 cases） and OSAHS severe group （OM-C group, 36 cases）, difference and correlation in clinical data and 25（OH）D3 were compared. Results HOMA-IR for T2DM group was significantly lower than the OM-B and OM-C groups, and the difference was statistically significant （ F = 18.24, P d0.05）. Between the OM-C group and the T2DM group, there was significant difference in course of TG （ F = 40.18, P ~ 0.05）. Between the four groups, there was significant difference in course of 2hPG, 25（OH）D3 and SaO2 min （ F = 29.54,32.16,24.27, P 〈0.05）, Correlation analysis shows 25 （OH）D3 were negati-Je eorrrelated with AHI, 2hPG （ P〈0.05）, 25 （OH）D3 was positively correlated with SaO2min （P〈0.05）. Conclusions 25 （OH）D3 is related significantly to OSAHS in patients with type 2 diabetes.
作者
朱震宏
蒋晓真
顾佩莉
周斌
徐凌燕
邹字峰
陈蕊华
Zhu Zhenhong Jiang Xiaozhen Gu Peili Zhou Bin Xu Lingyan Zou Yufeng Chen Ruihua(Department of Endocrinology, Shanghai Pudong Peoplels Hospital, Shanghai 201200, China)
出处
《国际呼吸杂志》
2017年第19期1472-1475,共4页
International Journal of Respiration
