摘要
目的探讨草酸艾司西酞普兰与度洛西汀合并奥氮平治疗躯体症状障碍的疗效及安全性。方法 114例躯体症状障碍患者随机分为2组,研究组即草酸艾司西酞普兰合并小剂量奥氮平进行治疗,对照组即度洛西汀合并小剂量奥氮平进行治疗,疗程均为8周。治疗前与治疗第2、8周采用患者健康问卷躯体症状群量表(PHT-15)、抑郁自评量表(SDS)、焦虑自评量表(SAS)评定临床症状,采用临床疗效总评量表(CGI-GI)进行疗效评估,采用副反应量表(TESS)评定副反应。结果 2组治疗前后PHT-15、SDS、SAS评分存在显著性差异(P<0.05);治疗2周末,2组CGI-GI评分无统计学意义(P>0.05)。治疗8周末,2组CGI-GI评分存在统计学意义(P<0.05)。2组累计脱落人数比较显示,治疗后2周末、8周末研究组脱落人数显著低于对照组。2组恶心、呕吐人数比较显示,治疗2周末,研究组显著低于对照组;治疗8周末,2组间差异无统计学意义(P>0.05)。2组乏力人数比较显示,治疗2周末,研究组显著高于对照组治疗;8周末,2组间差异无统计学意义(P>0.05)。2组体重增加人数比较显示,治疗2周末、8周末,2组体重增高差异无统计学意义(P>0.05)。结论草酸艾司西酞普兰与度洛西汀合并小剂量奥氮平治疗躯体症状障碍,临床选药时,应综合考虑患者不同躯体症状表现、是否伴发躯体疾病、经济状况等合理选药,尽可能降低脱落率。
Objective To explore the effectiveness and safety of escitalopram oxalate and duloxetine with olanzapine to treat so- matoform disorders. Methods 114 patients were randomly divided into study group and control group. The study group were treated by escitalpram oxalate with low - dose olanzapine, the control group were treated by duloxetine with low - dose olanzapine for 8 weeks. The patients were assessed before and 2,8 weeks after the treatments with PHT -15 ,SDS and SAS,and the clinical symptoms,the clinical ef- ficacy, and the side effects were evaluated. Results The scores of PHT - 15, SDS and SAS in two groups had significant difference （ P 〈 0.05 ）, Two weeks after the treatment, the scores of CGI - GI between the two groups was not different （ P 〉 0.05 ）. 8 weeks after the treatment, the difference was statistically significant of CGI - GI （ P 〈 0.05 ）. Compared the drop - out patients of two groups： after treat- ment in two and 8 weeks, drop - out patients of study group was obviously less than that in case - control group. Compared the side effect of nausea and vomiting patients in two groups ： after two weeks treatment, study group had less than that in case - control group, after 8 weeks treatment, difference of two groups had no statistical significance （ P 〉 0.05 ）. Compared the weakness of two groups ： after 2 weeks treatment, the study group was obviously higher than the control group, after 8 weeks treatment, difference of two groups had no statistical significance （ P 〉 0.05）. Conclusion Treatment by using escitalopram oxalate and duloxetine with lower dose of olanzapine has no the similar effect,while choosing medicine in clinical treatment,it should be considered that the patients are differentiate in physical symp- toms, whether or not concomitant physical disease and economical condition, and reduce the rate of drop - out.
作者
刘竹华
王媛
康玉琦
LIU Zhuhua WANG Yuan KANG Yuqi.(Psychological Center ,Ningxia Medical University, Yinchuan 750004, Chin)
出处
《宁夏医学杂志》
CAS
2017年第9期794-796,共3页
Ningxia Medical Journal
基金
宁夏科技支撑计划项目(201526)
关键词
草酸艾司西酞普兰
度洛西汀
奥氮平
躯体症状障碍
Escitalopram Oxalate
Duloxetine
Olanzapine
Physical Symptoms Related Disorders
