摘要
背景轻度认知功能障碍（mild cognitive impairment，MCI）是一种介于正常老化及痴呆之间的认知功能减退状态，不稳定，具有转化为痴呆的高风险。不同麻醉药对MCI可产生不同影响，对于术前已存在MCI的患者，如果麻醉药物选择不当。将直接加重脑损害、抑制脑功能，甚至加速MCI向痴呆转化。目的探究MCI研究进展及麻醉药影响。内容综述MCI定义、诊断标准、神经病理学、与阿尔茨海默病（Alzheimer＇s disease，AD）及帕金森病（Parkinson＇s disease，PD）的关系、麻醉药对MCI的影响。趋向通过对MCI深入研究，可以为MCI早期诊断及干预提供依据，也为该类患者围手术期合理选择麻醉药提供新思路。
Background Mild cognitive impairment （MCI） is an unstable cognitive decline which is seen as an intermediate stage between normal aging and dementia, with high risks of dementia. Anesthetics may exert different influence on MCI patients. If anesthetics are used improperly in MCI patients, brain damage will be directly aggravated, brain functions be inhibited, and the conversion of MCI to dementia be even accelerated. Objective To explore the research progress in mild cognitive impairment and the influence of anesthetics. Content This review discussed knowledge regarding MCI, including definitions, diagnostic criteria, neuropathology, the relationship between MCI and Alzheimer＇s disease （AD） or Parkinson＇s disease （PD）, anesthetics＇ influence on MCI. Trend The current study on MCI can provide with new tools to identify and hopefully treat MCI, and also provide thoughts for reasonable selection and application of anesthetics.
出处
《国际麻醉学与复苏杂志》
CAS
2017年第9期842-846,共5页
International Journal of Anesthesiology and Resuscitation
关键词
轻度认知障碍
阿尔茨海默病
帕金森病
麻醉
Mild cognitive impairment
Alzheimer＇s disease
Parkinson＇s disease
Anesthesia
