摘要
目的分析肌氨肽苷注射液联合α-硫辛酸治疗糖尿病周围血管神经病变的临床疗效。方法选取2016年1月—2017年1月在菏泽市立医院接受治疗的糖尿病周围血管神经病变患者80例,随机分成对照组(40例)和治疗组(40例)。对照组患者静脉滴注硫辛酸注射液,300 mg加入250 m L生理盐水,1次/d。治疗组在对照组的基础上静脉滴注肌氨肽苷注射液,10 m L加入250 m L生理盐水,1次/d。两组患者均治疗2周。评价两组患者临床疗效,同时比较治疗前后两组患者神经传导速度、血清学指标和TCSS评分。结果治疗后,对照组和治疗组的总有效率分别为62.50%、87.50%;两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者腓总神经、胫前神经运动传导速度(MCV)和感觉神经传导速度(SCV)均显著增加(P<0.05);且治疗组神经传导速度增加的更显著(P<0.05)。治疗后,两组血清内皮素(ET)水平明显降低,一氧化氮(NO)、超氧化物歧化酶(SOD)水平明显增高,同组比较差异具有统计学意义(P<0.05);且治疗组上述指标显著优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组TCSS评分均降低(P<0.05);且治疗组比对照组降低的更显著(P<0.05)。结论肌氨肽苷注射液联合α-硫辛酸治疗糖尿病周围血管神经病变具有较好的疗效,有利于临床症状的改善,还可提高神经传导速度,具有一定的临床推广应用价值。
Objective To analysis the clinical efficacy of Muscular Amino Acids and Peptides and Nucleosides Injection combined withα-thioctic acid in treatment of diabetic peripheral neuropathy.Methods Patients （80 cases） with diabetic peripheral neuropathy in Heze Municiple Hospital from January 2016 to January 2017 were randomly divided into control （40 cases） and treatment （40 cases） groups. Patients in the control group were ivadministered with Thioctic Acid Injection, 300 mg added into normal saline 250 mL, once daily. Patients in the treatment group were iv administered with Muscular Amino Acids and Peptides and Nucleosides Injection on the basis of the control group, 10 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the nerve conduction velocity, serum indexes, and TCSS scores in two groups before and after treatment were compared.Results After treatment, the clinical efficacy in the control and treatment groups were 62.50% and 87.50%, respectively, and there were differences between two groups （P 〈 0.05）. After treatment, the common peroneal nerve velocity, MCV, and SCV in two groups were significantly increased （P 〈 0.05）. And the increase of the nerve conduction velocity in the treatment group was more significantly than that in the control group （P 〈 0.05）. After treatment, the ET level in two groups was significantly decreased, NO and SOD levels were significantly increased, the difference was statistically significant in the same group （P 〈 0.05）. And these indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups （P 〈 0.05）. After treatment, the TCSS scores in two groups were significantly decreased （P 〈 0.05）. And the increase of the TCSS score in the treatment group was more significantly than that in the control group （P 〈 0.05）.Conclusion Muscular Amino Acids and Peptides and Nucleosides Injection combined with thioctic acid has a significant effect in treatment of diabetic peripheral neuropathy, can effectively improve the clinical symptoms and nerve conduction velocity, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2017年第9期1664-1667,共4页
Drugs & Clinic
关键词
肌氨肽苷注射液
硫辛酸注射液
糖尿病周围血管神经病变
腓总神经
感觉神经
内皮素
Muscular Amino Acids and Peptides and Nucleosides Injection
α-Thioctic Acid Injection
diabetic peripheral neuropathy
common peroneal nerve
sensory nerve
ET
