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龙血竭胶囊粉外敷治疗压疮疗效的Meta分析 被引量:9

Effect of resina draconis for external application on pressure ulcers:a Meta-analysis
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摘要 目的 系统评价龙血竭胶囊治疗压疮的临床疗效及安全性.方法 计算机检索PubMed、Embase、The Cochrane Library、CBM、CNKI、VIP和WanFang Data数据库,检索时限均为建库至2016年8月.由2名评价者独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析.结果 最终纳入36个RCT,共计1902例患者.Meta分析结果显示:在总有效率方面,龙血竭胶囊组显著优于常规消毒防腐剂组[RR=1.24,95%CI(1.15,1.34),P<0.00001]和抗生素组[RR=1.17,95%CI(1.09,1.26),P<0.0001],与湿润烧伤膏组比较差异无统计学意义[RR=1.36,95%CI(0.88,2.11),P=0.17];在治愈率方面,龙血竭胶囊组显著优于常规消毒防腐剂组[RR=1.87,95%CI(1.41,2.49),P<0.00001]和抗生素组[RR=2.11,95%CI(1.77,2.51),P<0.00001],与湿润烧伤膏组比较差异无统计学意义[RR=1.54,95%CI(1.00,2.38),P=0.05];在疮口愈合时间方面,龙血竭胶囊组显著优于常规消毒防腐剂组[MD=-10.50,95%CI(-15.52,-5.48),P<0.0001]、抗生素组[MD=-8.59,95%CI(-11.45,-5.73),P<0.00001]和湿润烧伤膏组[MD=-7.00,95%CI(-8.34,-5.66),P<0.00001].均无明显不良反应发生.结论 目前的证据表明,龙血竭胶囊粉外敷治疗压疮的疗效显著优于常规消毒防腐剂、抗生素及湿润烧伤膏. Objective To systematically review the efficacy and safety of resina draconis capsule in the treatment of pressure ulcers.Methods We searched the PubMed,Embase,The Cochrane Library,CBM, CNKI,VIP,and WanFang Data from their inception to August 2016. Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies. The meta-analysis was performed by using RevMan 5.3 software.Results A total of 36 RCTs involving 1902 patients were included. The results of meta-analysis showed that:as for the total effective rate,resina draconis capsule was superior to conventional disinfectant/preservative [RR=1.24, 95%CI(1.15,1.34),P〈0.00001] and antibiotics [RR=1.17,95%CI (1.09,1.26),P〈0.0001],and there was no significant difference with Shirun Shaoshang cream [RR=1.36, 95%CI(0.88,2.11),P=0.17]. In terms of recovery rate,resina draconis capsule was superior to conventional disinfectant/preservative [RR=1.87,95%CI(1.41,2.49),P〈0.00001] and antibiotics [RR=2.11,95%CI (1.77,2.51),P〈0.00001],and there was no significant difference with Shirun Shaoshang cream [RR=1.54, 95%CI (1.00,2.38),P=0.05]. As regard to the wound healing time,resina draconis capsule was superior to conventional disinfectant/preservative [MD=-10.50,95%CI(-15.52,-5.48),P〈0.0001],antibiotics [MD=-8.59,95%CI(-11.45,-5.73),P〈0.00001],and Shirun Shaoshang cream [MD=-7.00,95%CI (-8.34,-5.66),P〈0.00001]. No obvious event of adverse effect was reported.Conclusions According to the current evidence,the efficacy of resina draconis capsule is superior to conventional disinfectant/preservative, antibiotics,and Shirun Shaoshang cream in treatment of pressure ulcers.
出处 《中华现代护理杂志》 2017年第23期3016-3024,共9页 Chinese Journal of Modern Nursing
关键词 压力性溃疡 龙血竭 随机对照试验 META分析 Pressure ulcers Resina draconis Randomized controlled trial Meta-analysis
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