摘要
目的探讨术前负荷量阿托伐他汀对急性ST段抬高型心肌梗死(STEMI)患者急诊PCI术中无复流现象(NRP)及心功能的影响。方法 140例因STEMI行PCI术患者随机分为研究组和对照组,每组70例。对照组予常规治疗,研究组在此基础上予80 mg阿托伐他汀嚼服,观察两组术中心肌梗死溶栓(TIMI)血流分级、NRP发生率及术后N端B型利钠肽前体(NT-pro BNP)水平、心功能指标等情况。结果研究组NRP发生率明显低于对照组(17.1%vs 32.9%,P<0.05)。术后3 d及1、3、6个月两组患者的NT-pro BNP、左室舒张末容积指数(LVEDVI)、左室收缩末容积指数(LVESVI)水平呈下降趋势,左室射血分数(LVEF)呈升高趋势,且以研究组更为显著(P<0.05)。结论急诊PCI术前负荷量阿托伐他汀可有效预防STEMI患者术中NRP的发生,并对心功能有积极的影响。
Objective To investigate the effect of preoperative loading of atorvastatin on no-reflow phenomenon （NRP） and cardiac function in the patients with acute ST-segment elevation myocardial infarction （STEMI）. Methods 140 cases with STEMI receiving PCI were randomly divided into Study Group and Control Group, 70 cases in each group. Study Group received conventional treatment while Study Group was administered with 80 mg atorvastatin by chewing. The TIMI flow grades, NRP incidence, NT-proBNP level and cardiac parameters in the two groups were observed. Results The NRP incidence in Study Group was significantly lower than that in Control Group （17.1% vs 32.9%, P〈0.05）. The LV-proBNP, left ventricular end-diastolic volume index （LVEDVI） and left ventricular end-systolic volume index （LVESVI） in both groups were decreased 3 d and 1, 3 and 6 months after operation. The left ventricular ejection fraction （LVEF） showed an increase tendency, and more significantly increased in Study Group （P〈0.05）. Conclusions The amount of atorvastatin in the patients with emergency PCI can effectively prevent the incidence of NRP in STEMI patients and have a positive effect on their cardiac function.
出处
《广东医科大学学报》
2017年第3期278-281,共4页
Journal of Guangdong Medical University
关键词
阿托伐他汀
心肌梗死
心功能
atorvastatin
myocardial infarction
cardiac function
