摘要
目的:研究食管癌放、化疗前后血清癌胚抗原(CEA)、鳞状上皮细胞癌相关抗原(SCC)和细胞角化素蛋白片段(CYFRA21-1)的变化。方法:选2014年至2016年接受放化疗的食管癌100例作为研究组,健康体检者26例为对照组。采用酶联免疫吸附法(ELISA)检测患者血清治疗前、后CEA、SCC、CYFRA21-1水平,分析治疗前后的变化,以及与病理类型、肿瘤浸润度、TNM分期的关系。结果:治疗前研究组血清CEA、SCC、CYFRA21-1水平均明显高于对照组(P<0.05),治疗后研究组均有明显下降(P<0.05);与不同病理分期、肿瘤浸润深度、TNM分期差异明显,其中Ⅲ期、T4期最高(P<0.05)。但与对照组比较无差异(P>0.05)。结论:血清CEA、SCC、CYFRA21-1在不同病理分期、TNM分期及放化疗前后的食管癌患者血清含量不同,对于食管癌患者制定个性化治疗方案以及观察疗效有重要意义。
Objective：To study the changes of serum carcinoembryonic antigen （CEA）,squamous cell carcinoma antigen （SCC） and the cell keratin protein fragment （CYFRA21-1） in patients with esophageal cancer pre＆post radio-chemotherapy.Methods：Totally data of 100 patients with esophageal cancer underwent radio-chemotherapy were selected as experimental group,another 26 physical volunteers as control.The serum content of CEA,SCCa and YFRA21-1 were detected by using ELISA before and after radio-chemotherapy of the patients.The level of the marks related to tumor infiltrating degree,TNM stage was analyzed statistically.Results：The levels of serum CEA,SCC,CYFRA21-1 were significantly higher than that of control group before treatment （P〈0.05）,but they decreased after treatment significantly （P〈0.05）.However there was no significant difference between the experimental and control group （P〉0.05）.It was found that the levels of CEA,SCC,CYFRA21-1 were significantly related to TNM stage,tumor infiltration （T4 highest） in patients with esophageal cancer （P〈0.05）.Conclusion：The level of serum CEA,SCC,CYFRA21-1 is respectively and significantly related with TNM stage,tumor infiltration and rediochemotherapy in patients with esophageal cancer.It might be helpful to make personalized treatment plane and to evaluate its effect for patients with esophageal cancer.
出处
《现代肿瘤医学》
CAS
2017年第22期3628-3631,共4页
Journal of Modern Oncology
基金
河南省科技攻关计划项目(编号:B20143341)
