摘要
目的探讨应用锶羟基磷灰石(Sr HAC)、硫酸钙骨水泥(CSC)行椎体后凸成形术对骨质疏松性椎体压缩骨折模型的修复能力。方法收集21个新鲜冰冻的形态完好的人胸腰段(T10~L3)椎体作为实验标本,将椎体随机分为3组,每组7个椎体。其中A组为Sr HAC组,B组为CSC组,C组为PMMA作为对照组。测量各椎体的骨密度、原始高度,建立压缩骨折模型,再在C臂机下行椎体后凸成形术(PKP),分别对各组椎体原始强度、刚度,PKP术后椎体的强度、刚度以及术前、术后椎体压缩率和骨水泥注射量进行数据分析。结果 3组椎体的骨密度、原始强度、原始刚度和注射量组间无显著性差异(P>0.05)。各组椎体成形材料均能有效恢复伤椎高度,术后压缩率与术前压缩率相比均有显著性差异(P<0.05),而各组间术前、术后压缩率相比无显著性差异(P>0.05)。3组椎体术后刚度均未能恢复到原始水平,术后刚度较术前刚度均明显增加,差异有统计学意义(P<0.05),术后强度与原始强度相比较,差异均无统计学意义(P>0.05)。各组间术后刚度和术后强度,差异均无统计学意义(P>0.05)。结论应用Sr HAC和CSC行椎体后凸成形术能有效修复骨质疏松性椎体压缩骨折的高度和恢复生物力学性能。
Objective To explore the model repair capacity about SrHAC and CSC bone ce- ment applied to vertebral plasty to osteoporotic vertebral compression fractures. Methods Twenty-one fresh frozen thoracic lumbar segment （ of T10 - L3 ） vertebral body were collected as experimental specimens and randomly divided into 3 groups, each group had seven vertebral body. The group A for SrHAC group, group B for CSC group, and group C for PMMA as con- trol group. Bone mineral density and the original height of each vertebral body were measured, compression fracture model was established, and they were perated by C arm machine （PKP holds）. Then each vertebral strength and rigidity, the original PKP holds the postoperative ver- tebral strength, stiffness and preoperative and postoperative vertebral compression ratio and bone cement injection quantity were measured separately and analyzed statistically. Results The vertebral body bone mineral density, the strength of the original, original stiffness and in-jection volume had no significant difference between three groups （ P 〉 0. 05 ）. Both materials effectively restored vertebral body height. In each group, postoperative compression ratio com- pared with the preoperative compression rate had significant difference （ P 〈 0. 05 ）, but the preoperative and postoperative compression ratio had no significant difference among groups （P 〉 0. 05 ）. Three groups of vertebral body stiffness failed to restore to the original level, postop- erative stiffness compared with preoperative stiffness were significantly increased, the difference was statistically significant （P 〈 0.05 ）, and postoperative strength had no statistically signifi- cant difference compared with the original strength （ P 〉 O. 05 ）. Postoperative stiffness and strength, differences between groups had no statistical significance （P 〉 0. 05）. Conclusion Application of SrHAC and CSC by percutaneous kyphoplasty can effectively repair the height of the osteoporotic vertebral compression fractures and restore biomechanical properties.
出处
《哈尔滨医科大学学报》
CAS
2017年第4期312-316,共5页
Journal of Harbin Medical University
基金
黑龙江省卫生计生委科研课题(2016-197)
关键词
骨水泥
椎体压缩骨折
生物力学
椎体后凸成形术
bone cement
vertebral compression fractures
biomechanics
percutaneous kyphoplasty
