摘要
目的探讨急性心梗（AMI）合并哮喘患者的血清脂质水平与患者病死率的相关性。方法回顾性分析2014年3月至2016年12月本院收治的AMI合并哮喘的患者230例，采用酶学法检测血清中总胆固醇（TC）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）水平，并应用Friedewald公式计算低密度脂蛋白胆固醇（LDL-C）水平，同时采用免疫比浊法检测血清中载脂蛋白（apo）A和apoB水平。比较存活者和死亡者血清中血脂水平，同时比较不同血脂指标水平与AMI合并哮喘患者存活率的相关性。结果存活患者血清中TC、TG、LDL—C和apoB水平明显低于死亡患者，而HDL—C和apoA水平显著高于死亡患者，且差异均有统计学意义（均P〉0．05）；患者血清中TC≥6．2mmol／L、TG〉2．3mmol／L、LDL—C〉4．11mmol／L、HDL-C〈0．91mmol／L、apoA〈1．0g／L和apoB〉1．2g／L，其病死率明显升高（P〈0．05）。结论AMI合并哮喘的死亡患者血清中血脂水平异常，并且与患者的病死率密切相关，为临床上治疗提供新的思路，值得在临床上广泛应用。
Objective To explore the correlation between serum lipid levels and mortality in patients with acute myocardial infarction （AMI） complicating asthma. Methods 230 patients with AMI complicating asthma treated at our hospital from March, 2014 to December, 2016 were retrospectively analyzed. The serum levels of total cholesterol （TC）, triglyceride （TG）, and high-density lipoprotein cholesterol （HDL-C） were detected by enzyme method; and the level of low-density lipoprotein cholesterol （LDL-C） was calculated with Friedewald formula. Meanwhile, the serum levels of apolipoprotein （apo） A and apo B were detected by immune turbidimetric method. The serum lipid levels of the surviving patients and the dead patients were compared; at the same time, the correlation between the levels of different blood lipid and the survival rate of the patients with AMI complicating asthma was analyzed. Results The serum levels of TC, TG, LDL-C, and apo B were significantly lower and the levels of HDL-C and apo A were significantly higher in the survival patients than in the dead patients, with statistical differences （all P 〉 0.05）. The mortality of the patients with TC ≥6.2 retool/L, TG 〉 2.3 mmol/L, LDL-C 〉 4.11retool/L, HDL-C 〈 0.91 mmol/L, apo A 〈 1.0 g/L and, apo B 〉 1.2g/L increased significantly （P 〈 0.05）. Conclusions The serum lipid levels of patients with AMI complicating asthma areabnormal; the serum lipid levels closely associate with mortality, which provides new ideas for clinical treatment. So It is worth being clinically generlaized.
出处
《国际医药卫生导报》
2017年第19期3013-3016,共4页
International Medicine and Health Guidance News
关键词
急性心梗
哮喘
血脂
病死率
相关性
Acute heart attack
Asthma
Blood lipid
Mortality
Correlation
