摘要
目的观察奥氮平片联合艾司西酞普兰片治疗老年抑郁症的临床疗效及安全性。方法将80例老年抑郁症患者随机分为对照组40例和试验组40例。对照组予以艾司西酞普兰10 mg,qd,口服,一周内加至15~20mg·d^(-1).;试验组在对照组治疗的基础上,予以奥氮平2.5 mg,qd,口服,1周内加至5.0 mg·d^(-1)。2组患者均治疗8周。比较2组患者的临床疗效和药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为100.00%(40/40例)和77.50%(31/40例),差异有统计学意义(P<0.05)。2组患者的药物不良反应以头痛、恶心呕吐和乏力为主,试验组和对照组的药物不良反应发生率分别为12.50%和15.00%,差异无统计学意义(P>0.05)。结论奥氮平片联合艾司西酞普兰片治疗老年抑郁症的临床疗效确切,且不增加药物不良反应的发生率。
Objective To observe the clinical efficacy and safety of olanzapine tablets combined with escitalopram tablets in the treatment of senile depression. Methods A total of 80 patients with senile depression were randomly divided into the control group and treatment group with 40 cases per group. Control group was given escitalopram 10 mg,qd and the dosage was added to 15-20 mg,qd within the first week. Treatment group was given olanzapine 2. 5 mg,qd and the dosage was added to 5. 0 mg,qd within the first week,on the basis of control group. Two groups were treated for 8 weeks. The clinical efficacy and adverse drug reactions were compared between two groups. Results After treatment,the total effective rates in treatment and control groups were 100. 00%（ 40/40 cases） and 77. 50%（ 31/40 cases） with significant difference（ P〈0. 05）. The adverse drug reactions in two groups were headache,nausea,vomiting and fatigue,the incidences of adverse drug reactions in treatment and control group were 12. 50% and 15. 00% without significant difference（ P〉0. 05）. Conclusion Olanzapine tablets combined with escitalopram tablets have a definitive clinical efficacy and safety in the treatment of senile depression.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2017年第19期1900-1902,共3页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金青年科学基金资助项目(81301150)
河北省医学科学研究重点课题计划基金资助项目(20150186)
河北省科学技术研究与发展计划基金资助项目(152777153)
