摘要
目的:分析老年脑梗死并发尿道感染的病原菌分布及其耐药性。方法:选取2014年9月-2016年9月于我院治疗的240例老年脑梗死并发尿道感染患者为研究对象,收集患者中段尿标本进行细菌分离培养鉴定,分析病原菌分布情况并测定其耐药性。结果:共检出160株病原菌,其中革兰阴性菌108株,占67.50%,革兰阳性菌43株,占26.88%,真菌9株,占5.63%,前五位病原菌分别为大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌、溶血性葡萄球菌及粪肠球菌。在主要革兰阴性菌中,大肠埃希菌对头孢曲松耐药率最高(69.81%),对亚胺培南最敏感(3.77%);铜绿假单胞菌对环氧沙星耐药率最高(88.24%),对头孢曲松、头孢唑啉、头孢他啶、阿米卡星、哌拉西林、亚胺培南最敏感,耐药率均为0.00%;肺炎克雷伯菌对头孢唑林耐药率最高(75.00%),对呋喃妥因最敏感(6.25%)。在主要革兰阳性菌中,金黄色葡萄球菌对红霉素耐药率最高(85.71%);肠球菌属(粪肠球菌及屎肠球菌)对氨苄西林耐药率最高(70.00%);凝固酶阴性葡萄球菌(溶血性葡萄球菌及表皮葡萄球菌)对头孢曲松耐药率最高(93.75%);主要革兰阳性菌对万古霉素、利奈唑胺最敏感,耐药率均为0.00%。结论:老年脑梗死并发尿道感染病原菌种类多,应根据耐药性结果合理选用抗生素。
Objective： To analyze the distribution and drug resistance of pathogenic bacteria in elderly patients with cerebral infarcfion complicated with urinary tract infections. Methods： A total of 240 elderly patients with cerebral infarction complicated with urinary tract infections）who were treated in Tianjin Integrated Traditional Chinese and Western Medicine Hospital from September 2014 to September 2016, were chosen as research subjects. The urine specimen of the patients were Collected for bacterial isolation and culture identification; the distribution of pathogenic bacteria and the drug resistance were analyzed. Results： A total of 160 strains of pathogenic bacteria were detected. Among them, there were 108 strains of gram negative bacteria, accounting for about 67.50%;43 strains of gram positive bacteria, accounting for 43; and 9 strains of fungi accounting for 5.63%. The top five pathogenic bacteria were escherichia coli, pseudomonas aeruginosa, klebsiella pneumoniae, staphylococcus aureus and enterococcus faecalis. In the main gram negative bacteria, the escherichia coli resistance to ceffriaxone was the highest （69.81%）, and the most sensitive to imipenem （3.77%）. The pseudomonas aeruginosa resistance to epoxy was the highest （88.24%）, and the most sensitive to cefatriaxone, cefazolin, ceftazidime, amikacin, piperacillin and imipenem, the drug resistance rates were 0.00%. The klebsiella pneumoniae resistance to cefazolin was the highest （75.00%）, and the most sensitive to nitrofurantoin （6.25%）. In the main gram positive bacteria, the staphylococcus aureus resistance to erythromycin was the highest （85.71%）. The enterococcus （enterococcus faecalis and enterococcus faecium） resistance to ampicillin was the highest（70.00%）; The coagulase negative staphylococcus（hemolytic Staphylococcus and staphylococcus epidermidis） resistance to ce- fatriaxone was the highest（93.75%）. The main gram positive bacteria were sensitive to vancomycin and linezolid, the drug resistance rates were 0.00%. Conclusion： There are various pathogenic bacteria causing urinary tract infections in elderly patients with cerebral infarction, The antibiotics drugs should be rationally used according to the results of drug resistance.
出处
《现代生物医学进展》
CAS
2017年第29期5720-5723,5756,共5页
Progress in Modern Biomedicine
基金
天津市卫生局科技基金项目(2014KZ051)
关键词
老年
脑梗死
尿道感染
病原菌
耐药性
Elderly
Cerebral infarction
Urinary tract infection
Pathogenic bacteria
Drug resistance
