摘要
目的:观察金黄散外敷联合吲哚美辛治疗急性痛风性关节炎(AGA)的临床疗效和安全性。方法:58例初发AGA患者随机分为两组。对照组给予吲哚美辛治疗,观察组在对照组基础上外敷金黄散。两组疗程均为7 d。观察两组患者的临床疗效、关节症状改善和实验室指标恢复情况及药品不良反应。结果:观察组总有效率为93.10%,明显高于对照组的72.41%(P<0.05)。总体疗效比较,观察组优于对照组(P<0.01)。治疗后,两组患者的关节疼痛、肿胀和活动受限评分及红细胞沉降率(ESR)、白细胞计数(WBC)和血尿酸(BUA)水平均较治疗前下降(P<0.01);且观察组患者症状评分及实验室指标水平均优于对照组(P<0.05和P<0.01)。两组药品不良反应症状均较轻微,发生率差异无统计学意义(P>0.05)。结论:金黄散外敷联合吲哚美辛治疗AGA能有效改善关节症状,降低血尿酸及炎症指标水平,疗效显著。
Objective：To study the clinical efficacy and safety of Jinhuang powder combined with indomethacin in the af aeate gouty arthritis（AGA）. Methods：58 cases of AGA patients who received treatment in the hospital were randomly dimmed into two groups. The control group was treated with indomethacin, and the observation group was igivma Jilnmlg powder eombined lla indomethacin additionnally. The course was 7 days. The clinical symptoms, laborato- index, tim eFmieal efficacy and incidence of adverse drug reaction were observed. Results：The total efficiency for pa in the obsemcation group was 93.10%, which was significant higher than that of control group（ P 〈 O. 05 ）, which was 72.41%. While compared the total clinical efficacy, the observation group was superior to the control group. After treat- mtt, the. eores of joint symptom and the levels of ESR, BUA, WBC were all decreased in both groups than before（P 〈 0,01 ） and the changes of scores of joint symptom and laboratory index in the observation group were significantly better the control group（P 〈 O. 05 and P 〈 O. Ol ）. There was no significant difference in two groups while compared the ndvere drag reaction during the treatment（ P 〉 0. 05 ）. Conclusion： In the treatment of gouty arthritis, Jinhuang powder combined with indomethacin could obviously improve the joint symptoms, low down the levels of BUA and inflammatory in- dex, and it had good clinical efficacy.
出处
《药物流行病学杂志》
CAS
2017年第10期665-667,695,共4页
Chinese Journal of Pharmacoepidemiology
关键词
金黄散
吲睬羡辛
急性痛风性关节炎
临床疗效
Jinhuang powder
Indomethacin
Acute gouty arthritis
Clinical efficacy
