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七白颗粒对女性黄褐斑气滞血瘀证患者抗氧化作用及性激素水平的影响 被引量:19

Effect of Qibai Granules on Antioxidation and Sex Hormone Levels for Patients with Female Chloasma Qi Stagnation and Blood Stasis Syndrome
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摘要 目的:观察七白颗粒对女性黄褐斑气滞血瘀证患者抗氧化作用及性激素水平的影响,并探讨其作用机制。方法:按照治疗方案不同将126例女性黄褐斑气滞血瘀证患者分为治疗组(66例)和对照组(60例),治疗组患者给予七白颗粒治疗,对照组给予氢醌乳膏治疗,比较两组治疗效果。结果:治疗组患者治疗后8周皮损评分明显低于对照组(P<0.05);治疗组患者治疗总有效率和治疗总满意度明显高于对照组(P<0.05);治疗组患者治疗后超氧化物歧化酶(SOD),过氧化物酶(CAT)水平均明显高于对照组,丙二醛(MDA),雌二醇(E_2),促卵泡激素(FSH),黄体生成素(LH)水平低于对照组(P<0.05);两组患者安全分级比较差异无统计学意义;治疗组患者治疗后生存质量量表(WHOQOL-BREF)评分明显高于对照组(P<0.05)。两组患者不良反应比较差异无统计学意义,两组患者血常规、尿常规、大便常规、肝肾功能检查结果均无明显异常。结论:七白颗粒治疗对女性黄褐斑气滞血瘀证疗效显著,可有效改善患者皮损症状、性激素水平和生存质量,抗氧化效果明显,安全性高,患者没有明显不良反应,对血常规、尿常规、大便常规、肝肾功能无显著影响,可作为优选治疗方案。 Objective: To observe the effect of Qibai granules on antioxidation and sex hormone levels for the patients with female chloasma Qi stagnation and blood stasis syndrome. Method: The 126 cases of patients with female chloasma Qi stagnation and blood stasis syndrome were divided into observation group( 66 cases) and control group( 60 cases). Patients in observation group were treated by Qibai granules,while patients in control group were treated by hydroquinone cream. The clinical effects were observed and compared between two groups. Result: The scores of skin lesions for observation group were lower than those in control group at week 8( P〈0. 05). The total effective rate and total satisfaction for observation group were higher than those in control group( P〈0. 05). The levels of superoxide dismutase( SOD),cata-lase( CAT) for observation group were higher than those in control group( P〈0. 05). The levels of malondialdehyde( MDA),E_2,follicle-stimulating hormone( FSH),luteinizing hormone( LH) for observation group were lower than those in control group( P〈0. 05). There was no significant difference in safety classification between two groups. The scores of WHO Quality of Life Measure-Abbreviated version( WHOQOL-BREF) for observation group were higher than those in control group after treatment( P〈0. 05). There was no significant difference on the adverse reactions,and both groups showed no obvious abnormalities in results of blood routine,urine routine,stool routine,liver and kidney function tests. Conclusion: Qibai granules had good clinical effects for patients with female chloasma Qi stagnation and blood stasis syndrome; it can improve the skin lesions,the levels of sex hormone and quality of life,with obvious antioxidant effect,high safety,without obvious adverse reactions or significant effects on blood routine,urine routine,stool routine,liver and kidney function results,so it can be used as an optimal treatment plan.
出处 《中国实验方剂学杂志》 CAS CSCD 北大核心 2017年第20期163-168,共6页 Chinese Journal of Experimental Traditional Medical Formulae
基金 哈尔滨商业大学博士科研启动项目(13DL027)
关键词 黄褐斑 气滞血瘀证 七白颗粒 抗氧化 性激素 chloasma Qi stagnation and blood stasis syndrome Qibai granule antioxidation sex hormone
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