摘要
目的:探讨甲基苯丙胺依赖者脑结构的改变及其可能影响因素。方法:采用回顾性研究方法,通过病案库筛查2014年1月~2016年3月在我院物质依赖科住院的符合甲基苯丙胺依赖综合症诊断的患者,收集病史资料及头颅核磁共振(MRI)检查结果,经过入排标准筛查,最后纳入136例患者的资料进行统计分析。结果:头颅MRI发现有脑结构改变者71例(52.2%)。其中33例(24.2%)患者存在脑白质脱髓鞘改变,以额叶最多见,共30例;其次为侧脑室角5例;顶叶3例;放射冠区及右侧岛叶各1例。缺血灶15例(11.0%)。囊肿10例(7.4%),包括垂体Rathke’s囊肿7例,其他囊肿3例。脑沟增宽3例(2.2%)。其他异常17例(12.5%)。脑脱髓鞘病变与患者的性别、年龄、滥用甲基苯丙胺的年限无相关性(p>0.05)。结论:甲基苯丙胺依赖者脑结构改变常见,尤其是脑白质脱髓鞘病变,其原因未明。
Objective：To explore the change of structural brain in methamphetamine addicts and its possible influencing factors. Methods： By adopting the method of retrospective study,screening the patients conforming to methamphetamine dependence syndrome diagnosis in substance dependence ward of our hospital from January 2014 to March 2016, the data of 136 patients who met the criteria of entry and exclusion were included in the statistical analysis. Results： The results showed that there were 71 cases of abnormal magnetic resonance, which accounted for 52.2 % of the total. There were 33 cases of white matter demyelination, accounting for 24.2 % of the total, including 30 cases of the lesion in the frontal lobe, 5 in the lateral ventricle, and 3 in the parietal lobes, 1 in the radiation crown and 1 the right island leaf. There were 15 cases of ischemia, accounting for 11.0% of the total. There were 10 cases of cysts, accounting for 7.4% of the total, including 7 cases of pituitary Rathke＇s cyst and 3 cases other cysts. Three cases showed that the gap widens, accounting for 2.2 % of the total. In addition, there were 17 casesofother abnormal results, accounting for 12.5%. Demyelinating were not associated with gender, age, and years of abuse of methamphetamine（p〈0.05）.Conclusion： Methamphetamine addicts often have brain structure changes, especially the white matter demyelination, the reason is not clear.
出处
《中国药物滥用防治杂志》
CAS
2017年第5期261-263,共3页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
甲基苯丙胺依赖者
核磁共振
脑结构
methamphetamine addict
nuclear magnetic resonance imaging
brain structure
