摘要
[目的]探讨影响肝癌患者预后的相关因素,为临床治疗和肝癌预防提供参考依据。[方法]选择1989年11月至2007年1月我院的1838例肝癌住院病例的临床及随访资料进行分析,分析筛选影响患者生存期的相关因素。[结果]肝癌住院患者1、3、5、10年生存率分别为52%、26%、17%和8%,中位生存期14个月,最长生存期190个月。Cox比例风险回归模型进行多因素分析显示性别、AFP、临床分期、大体分类、组织学分型、治疗方法不同的肝癌病例的生存率差异均有统计学意义(P<0.05)。[结论]性别、术前AFP量、临床分期、大体分类、组织学分型以及治疗方法对肝癌的预后生存期有显著性影响。
[Objective] To analyze prognosis and related influencing factors of hepatocellular carcinoma（HCC）. [Methods] Clinical and follow-up data of 1838 patients with HCC admitted in our hospital from 1989 to 2007 were retrospectively reviewed. The survival and the related influencing factors were analyzed. [Results] The 1-,3-,5-and 10-year overall survival was 52%,26%,17% and 8%,respectively with a median survival of 14 months and the maximal survival of 190 months. Cox proportional hazard regression model indicated that gender,AFP,clinical stage,gross type,histological type,treatment were the independent risk factors influencing the prognosis of hepatocellular carcinoma. [Conclusions] Gender,AFP,clinical stage,gross type,histological type,treatment are major influencing factors of the survival time of HCC patients.
出处
《肿瘤学杂志》
CAS
2017年第9期789-793,共5页
Journal of Chinese Oncology
基金
湖南省科技厅项目(2011FJ3188)
湖南省卫计委项目(C2015-53)
关键词
肝肿瘤
住院病例
生存分析
hepatocellular carcinoma
inpatients
survival
