摘要
间日疟地理分布广,是现今疟疾控制和消除的最大挑战之一。本文通过查阅各类相关数据库,综述了间日疟控制和消除的挑战及其应对策略研究进展。各类来源的研究资料显示间日疟更易于传播,媒介控制措施效果差;无症状和亚显微镜检测密度带虫者比例高,常规检测困难;磷酸伯氨喹啉(唯一根治药)安全性低。为应对这些挑战,现正在从传播阻断、实验诊断、抗疟药物和方案等方面开展研究。
Plasmodium vivax has the largest geographic distribution among malaria parasites. Control and elimination ofvivax malaria is one of the biggest challenges at present. This paper reviewed challenges and progress updates on control andelimination of Plasmodium vivax malaria through collecting various resources. These data show that Plasmodium vivax is moretransmissible and difficult to interrupt transmission, more undetectable by routine tests due to a high proportion of individualswith asymptomatic and submicroscopic parasite density, and low safety of primaquine（only available drug for radical cure）. Theresearches updated are strategies of interrupting transmission, laboratory test diagnosis and development of antimalarial drugsand treatment regimens.
出处
《中国热带医学》
CAS
2017年第10期1047-1051,共5页
China Tropical Medicine
基金
国家自然科学基金资助项目(No.81560543)
关键词
间日疟
消除疟疾
G6PD缺乏
根治
挑战
Plasmodium vivax
malaria elimination
G6PD deficiency
radical cure treatment
challenges
