摘要
大颗粒淋巴细胞白血病（large granular lymphocytic leukemia,LGLL）是一组少见的血液系统肿瘤,其主要临床特征为血液系统异常和免疫系统异常。国外有LGLL与类风湿关节炎、白塞氏病、血管炎的相关报道,2013年Audemard等曾报道11例LGLL患者合并血管炎,其中10例为TLGLL,以女性居多,主要累及小血管。迄今未见LGLL与中枢神经系统血管炎的相关性报道，我院收治1例，现报告如下，并对相关文献进行复习。
We detected monoclonal T lymphocyte by TCRβvariable region genes in a patient with T-large granular lymphocytic leukemia combined with central nervous system vasculitis.We also detected bone marrow cytology,cerebrospinal fluid cytology and flow cytometry,brain histopathology and imaging in the patient,in order to explore clinical features,pathogenesis,diagnosis,therapy and prognosis of T-large granular lymphocytic leukemia combined with central nervous system vasculitis.After treated with cyclophosphamide and dexamethasone in combination with intrathecal chemotherapy,cranial MRI showed placeholder lesions significantly narrowed.The patient returned to normal neurologic status.T-large granular lymphocytic leukemia may combine with central nervous system vasculitis,and early diagnosis and treatment can improve the curative effect.
出处
《临床血液学杂志》
CAS
2017年第5期719-722,共4页
Journal of Clinical Hematology
