摘要
目的观察盐酸法舒地尔联合长春西汀治疗后循环缺血性眩晕(PCIV)的临床疗效及安全性。方法将60例PCIV患者随机分为观察组和对照组,每组30例,两组患者均给予常规治疗以及长春西汀治疗,观察组加用盐酸法舒地尔治疗,两组疗程均为14 d。比较两组临床疗效以及治疗前后两组左椎动脉(LVA)、右椎动脉(RVA)、基底动脉(BA)的血流速度。结果观察组总有效率为96.67%,对照组为73.33%,观察组疗效优于对照组(P<0.05)。治疗后两组的LVA、RVA、BA的血流速度均快于治疗前,并且观察组血流速度快于对照组(P<0.05)。在治疗过程中,两组患者无严重不良反应发生。结论在常规治疗的基础上,盐酸法舒地尔联合长春西汀治疗PCIV疗效确切,可有效改善椎基底动脉血流速度。
Objective To observe the clinical efficacy and safety of fasudil hydrochloride combined with vinpocetine for the treatment of posterior circulation ischemic vertigo （PCIV）. Methods Sixty patients with PCIV were randomly divided into observation group and control group,with 30 cases in each group. Both groups received conventional treatment and were administered vinpocetine. Additionally,the observation group was treated with fasudil hydrochloride. The treatment lasted for 14 days in both groups. The clinical efficacy ,the blood flows of left vertebral artery（LVA） ,right vertebral artery（RVA） and basilar artery（BA） before and after treatment were compared between the two groups. Results The total effective rates of the observation group and the control group were 96.67% and 73.33% respectively, and the efficacy of the observation group was superior to that of the control group（P 〈 0. 05）. The blood flows of LVA,RVA and BA after treatment were faster than those before treatment in both groups （P 〈 0.05 ）, and the blood flows in the observation group were faster than those in the control group （ P 〈 0. 05 ）. No severe adverse reactions occurred in the two groups during the treatment. Conclusion On the basis of conventional treatment,fasudil hydrochloride combined with fluoxetine obtains a definite efficacy for PCIV and can effectively improve the blood flow of vertebral basilar artery.
作者
宋柳全
黎晓亮
姚洁文
梁炳松
SONG Liu-quan LI Xiao-liang YA O Jie-wen LIANG Bing-song(Department of Pharmacy Department of Neurology, Wuzhou Gongren Hospital, Wuzhou 543001, China)
出处
《广西医学》
CAS
2017年第10期1494-1496,共3页
Guangxi Medical Journal
基金
广西梧州市科学研究与技术开发计划(201402024)
关键词
后循环缺血性眩晕
盐酸法舒地尔
长春西汀
Posterior circulation ischemic vertigo, Fasudil hydrochloride, Vinpocetine
