摘要
目的探讨联合应用地黄益智方、电针及盐酸多奈哌齐片治疗阿尔茨海默型痴呆(AD)的临床效果。方法选择AD患者90例作为观察对象,应用随机数字表法将患者分为对照组及研究组,每组45例。其中对照组接受盐酸多奈哌齐片治疗,研究组接受地黄益智方、电针联合盐酸多奈哌齐片治疗,分析2组治疗前后HDS、ADL及中医症状评分变化情况,并对比2组治疗效果。结果治疗后2组HDS-R评分均呈升高趋势,ADL评分及中医症状积分均呈降低趋势;入组时及治疗4周时,2组间HDS-R评分、ADL评分及中医症状积分比较差异未见统计学意义(P均>0.05);而治疗12周时及治疗24周时,研究组HDS-R评分显著高于对照组(P均<0.05),ADL评分及中医症状积分显著低于对照组(P均<0.05)。在完成24周治疗后,研究组治疗总有效率高于对照组(P<0.05)。在接受治疗的24周期间内,2组治疗不良反应发生率比较差异未见统计学意义(P>0.05)。结论地黄益智方、电针联合盐酸多奈哌齐片可有效提高AD患者的近期治疗效果。
Objective It is to investigate the clinical effect of combined application of Huang Yizhi prescription,electroacupuncture combined with Donepezil Hydrochloride Tablets in the treatment of Alzheimer＇s dementia （AD）.Methods Ninety-nine cases were diagnosed as AD patients as research object,and randomly divided into control group and study group,45 cases in each group.The patients were treated with Donepezil Hydrochloride Tablets in the control group and with Dihuang Yizhi prescription,electroacupuncture combined with Donepezil Hydrochloride Tablets in the study group.The changes of HDS,ADL and TCM symptom score before and after treatment were analyzed and compared in two groups.Results After treatment,the HDS-R score were increased,ADL score and TCM symptom score were decreased; there was no significantly difference before treatment and treated for 4 weeks in HDS-R score,ADL score and TCM symptoms integral between the two groups （all P〈0.05）,however the HDS-R score of the study group was significantly higher and the ADL score and TCM symptom score were significantly lower than that of the control group after 12 and 24 weeks of treatment （all P〈0.05）.After 24 weeks of treatment,the total effective rate of the study group was higher than that of the control group （P〈0.05）.During the 24 weeks of treatment,there was no significant difference in the incidence of adverse reactions between the two groups （P〈0.05）.Conclusion Dihuang Yizhi prescription,electroacupuncture combine with Donepezil Hydrochloride Tablets can effectively improve the therapeutic effect in patients with AD.
出处
《现代中西医结合杂志》
CAS
2017年第30期3331-3333,3337,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
地黄益智方
电针
盐酸多奈哌齐片
阿尔茨海默型
痴呆
Dihuang Yizhi prescription
electroacupuncture
Donepezil Hydrochloride Tablets
Alzheimer s dementia
dementia
