摘要
目的分析伴发不安腿综合征（RLS）的帕金森病（PD）患者的临床特点。方法分析2014年2月至2016年12月期间99例PD患者和89名健康对照组的一般临床资料。采用非运动问卷（NMSquest）第6项调查结果来评估PD患者及健康对照组是否合并RLS；将PD患者分为RLS组和非RLS组，采用统一PD评分量表（UPDRS-Ⅲ）比较两组患者运动症状严重程度；采用贝克焦虑量表（BAI）、贝克抑郁量表（BDI）、中文版39项帕金森病生活质量问卷（PDQ-39）及UPDRS—1分别比较两组患者焦虑、抑郁、生活质量等情况。结果（1）PD患者中RLS的发生率为18．2％（18／81），显著高于对照组（P〈0．001）。（2）RLS组女性患者12例（66．7％），男性患者6例（33．3％）。（3）RLS组患者UPDRS—I评分[（20±7）分，P=0．008]，UPDRS-Ⅲ评分[（434-14）分，P=0．015]，BDIⅡ分[（234-13）分，P=0．002]，BAI评分[（184-8）分，P=0．012]，PDQ-39评分[（75±26）分，P=0．000]明显高于非RLS组。（4）RLS与PD患者在病程、年龄、PD发病年龄、等效多巴胺能剂量方面比较差异无统计学意义。结论RLS在PD患者中发生率更高，伴发RLS的PD患者女性多见、运动症状受累更严重、生活质量更差、更易伴发焦虑、抑郁症状。
Objective To study the clinical characteristics of Parkinson＇s disease （PD） patients with restless legs syndrome （RLS）. Methods Ninety-nine PD patients and eighty-nine control group were included into this study and assessed for RLS by the question 6 of the non-motor symptoms questionnaire （NMSquest）. The PD patients were divided into the RLS group and non RLS group, according to their answers to the NMSquest. The severity of motor symptoms, anxiety, depression and quality of life were evaluated according Unified Parkinson Disease Rating Scale （ UPDRS ）, Beck Anxiety Inventory （ BAI）, Beck Depression Inventory （BDI）, Parkinson＇ s Disease Quality Of Life Questionnaire （PDQ-39）, respectively. Results （ 1 ） 18.2% （ 18/81 ） of the PD patients experienced RLS, the incidence was significantly higher than the general population （P 〈 0. 001 ）. （2） The RLS patients were more often women （66. 7% vs 33.3%, P =0. 033 ）. （3） The UPDRS- Ⅱ score（20 ±7, P =0. 008）, UPDRS-Ⅲ score（43 ± 14, P = 0. 015 ）, BDI score（23 ± 13, P = 0. 002）, BAI score （ 18 4. 8, P = 0. 012 ）, PDQ-39 score （75 ± 26, P =0. 000）in RLS group were significantly higher compared with non RLS group. （4） RLS showed no association with the course of the disease, the age, the PD onset age and levodopa dose equivalents. Conclusions RLS more likely appears in PD patients, especially in women. The PD patients with RLS commonly suffer from serious motor symptom, low quality of life, anxiety and depression.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2017年第39期3089-3092,共4页
National Medical Journal of China
基金
武汉市科技局2015年应用基础研究计划项目（2015060101010047）
关键词
不安腿综合征
帕金森病
发生率
临床特征
Restless legs syndrome
Parkinson＇s disease
Incidence
Clinical manifestation
