摘要
目的比较不同剂量氟比洛芬酯超前镇痛用于腹腔镜术后镇痛的效果及安全性。方法选择医院2014年5月至2016年5月收治的择期行妇科腹腔镜手术患者400例,按随机数字表法分为A组和B组,各200例。A组患者术中给予氟比洛芬酯0.75 mg/kg,B组患者术中给予氟比洛芬酯1.0 mg/kg,比较两组患者手术前、麻醉时、术毕、术后2 h心率(HR)和平均动脉压(MAP),术后2,6,12 h疼痛视觉模拟评分(VAS)和不良反应发生情况。结果麻醉时、术毕、术后2 h,B组患者HR和MAP均显著低于A组(P<0.05);B组患者术后2,6,12 h VAS评分均显著低于A组(P<0.05);B组患者不良反应总发生率为11.50%,与A组的11.00%比较,差异无统计学意义(P>0.05)。结论 1.0 mg/kg氟比洛芬酯超前镇痛用于腹腔镜术后镇痛效果显著,且安全性较高。
Objective To compare the effect and safety of preemptive analgesia with different doses of flurbiprofen axetil for postopera-tive analgesia in laparoscopic surgery. Methods A total of 400 patients underwent elective gynecological laparoscopic surgery in our hospital from May 2014 to May 2016 were selected and randomly divided into group A and group B,200 cases in each group. The group A was treated with flurbiprofen axetil of 0. 75 mg/kg during surgery,while the group B was treated with flurbiprofen axetil of 1. 0 mg/kg during surgery. The heart rate（HR） and mean arterial pressure （MAP） before surgery,during anesthesia,at the end of surgery and at 2 h after surgery,visual analogue scale（VAS）scores at 2,6,12 h after surgery and adverse reactions were compared between the two groups. Results The HR and MAP of group B were significantly lower than those of group A during anesthesia,at the end of surgery and at 2 h after surgery（P 〈 0. 05）. The VAS scores of group B were significantly lower than those of group A at 2, 6,12 h after surgery（P 〈 0. 05）. There was no significant difference in the total incidence rate of adverse reactions between the two groups （11. 50% vs. 11. 00%,P 〉 0. 05）. Conclusion Preemptive analgesia with flurbiprofen axetil （1. 0 mg/kg）is effective and safe for postoperative analgesia in laparoscopic surgery.
出处
《中国药业》
CAS
2017年第20期46-48,共3页
China Pharmaceuticals
关键词
氟比洛芬酯
超前镇痛
腹腔镜手术
镇痛效果
安全性
flurbiprofen axetil
preemptive analgesia
laparoscopic surgery
analgesic effect
safety
