摘要
目的探讨双歧杆菌乳酸菌三联活菌片联合赖氨葡锌颗粒治疗小儿急性腹泻的临床疗效及对复发率的影响。方法选取2015年9月~2017年1月我院收治的86例急性腹泻患儿作为研究对象,采用随机数字表法将其分为两组,每组各43例。对照组患儿接受常规治疗(补水、纠正水电解质与酸中毒、给予双歧杆菌乳杆菌三联活菌片等),观察组患儿在对照组基础上使用赖氨葡锌颗粒。观察两组患儿治疗后临床疗效、胃肠道屏障功能、复发率。结果观察组患儿治疗后的总有效率(97.67%)明显高于对照组(81.40%),差异有统计学意义(P<0.05);治疗前,两组患儿二胺氧化酶(DAO)、D-乳酸、内毒素水平比较,差异无统计学意义(P>0.05);治疗后,观察组患儿DAO、D-乳酸、内毒素水平明显低于对照组,差异有统计学意义(P<0.05);观察组患儿治疗后1个月无复发,治疗后2个月复发率为4.65%,治疗后3个月为13.95%,对照组患儿分别为9.30%、20.93%、32.56%,差异均有统计学意义(P<0.05)。结论双歧杆菌乳杆菌三联活菌片联合赖氨葡锌片治疗小儿急性腹泻效果显著,可有效提高肠道屏障功能,降低复发率,值得临床推广。
Objective To investigate the clinical effects of Live Combined Bifidobacterium and Lactobacillus Tablets combined with Compound Lysine Hydrochloride and Zinc Gluconate Granules in the treatment of children with acute diarrhea and its influence on recurrence rate.Methods 86 cases of children with acute diarrhea who accepted treatments in our hospital from September 2015 to January 2017 were selected as the research objects,and were divided into two groups by the random number table method,43 cases in each group.The control group were received routine treatment （water supplement,correction of water,electrolyte and acidosis,and were given the live Combined Bifidobacterium and Lactobacillus Tablets,etc.）,while the observation group were treated with Compound Lysine Hydrochloride and Zinc Gluconate Granules on the basis of the control group.The clinical effects,gastrointestinal barrier function and recurrence rate after the treatment of two groups of patients were observed.Results The total effective rate after the treatment tin the observation group （97.67%） was higher than that in the control group （81.40%）,and the difference was statistically significant （P〈0.05）.Before the treatment,there was no significant difference in the diamine oxidas （DAO） and D-lactic acid and endotoxin levels between the two groups （P〉0.05）.After the treatment,the levels of DAO and D-lactic acid and endotoxin in the observation group were significantly lower than those in the control group, the difference was statistically significant （P〈0.05）.There was no recurrence in the observation group after the treatment for 1 months,recurrence rate after the treatment for 2 months was 4.65%,and 3 months was 13.95%,while the control group respectively were 9.30%,20.93%,32.56%,the differences were statistically significant （P〈0.05）.Conclusion The effect of Live Combined Bifidobacterium and Lactobacillus Tablets combined with Compound Lysine Hydrochloride and Zinc Gluconate Granules in the treatment of children with acute diarrhea are significant,which can effectively improve the intestinal barrier function and reduce the recurrence rate,thus it is worthy to be promoted in the clinical.
出处
《中国当代医药》
2017年第29期75-77,共3页
China Modern Medicine
关键词
赖氨葡锌
双歧杆菌乳杆菌三联活菌片
小儿急性腹泻
复发
Zinc Gluconate Granules
Live Combined Bifidobacterium and Lactobacillus Tablets
Children with acute diarrhea
Recurrence
