摘要
目的探讨复方竹叶石膏联合雷尼替丁治疗复发性口腔溃疡效果。方法选取山西省中医院99例复发性口腔溃疡患者,按照随机数字表法分组,对照组49例予以雷尼替丁治疗,观察组50例予以雷尼替丁+复方竹叶石膏颗粒治疗,观察比较两组临床疗效、溃疡复发情况,并统计两组溃疡愈合时间、溃疡疼痛评分(VAS)、溃疡疼痛持续时间及不良反应发生情况。结果观察组治疗总有效率为92.00%(46/50),高于对照组的67.35%(33/49),差异有统计学意义(P<0.05);观察组复发率为2.00%(1/50),低于对照组的16.33%(8/49),差异有统计学意义(P<0.05);观察组溃疡愈合时间及VAS评分、疼痛持续时间均小于对照组,差异具有统计学意义(P<0.05);观察组不良反应发生率为14.00%(7/50),对照组为12.24%(6/49),组间比较差异无统计学意义(P>0.05)。结论复方竹叶石膏颗粒联合雷尼替丁治疗复发性口腔溃疡效果显著,安全性高,复发率低,可改善疼痛症状,缩短溃疡愈合时间。
Objective To explore the effect of Compound Bamboo Leaf Gypsum granules combined with ranitidine in the treatment of recurrent oral ulcer. Methods 99 patients with recurrent oral ulcers in Shanxi Provincial Hospital of TCM were randomly divided into control group and observation group,with 49 cases each group. The control group was treated with ranitidine,and the observation group was treated with ranitidine and Compound Bamboo Leaf Gypsum granules. The clinical effect and ulcer recurrence of the two groups were compared,besides,ulcer healing time,ulcer pain（ VAS） score,duration of ulcer pain and adverse events of the two groups were analyzed as well. Results The total effective rate in the observation group and the control group was 92. 00%（ 46/50） and 67. 35%（ 33/49）respectively,and the difference was statistically significant（ P〈0. 05）; The recurrence rate in the observation group and the control group was 2. 00%（ 1/50） and 16. 33%（ 8/49） respectively,and the difference was statistically significant（ P〈0. 05）. The duration of ulcer healing,VAS score and pain duration in the observation group were lower than those in the control group,and the difference was statistically significant（ P〈0. 05）. The incidence of adverse reactions in the observation group and the control group was 14. 00%（ 7/50） and 12. 24%（ 6/49） respectively,and there was no significant difference between the two groups（ P〈0. 05）. Conclusion Compound Bamboo Leaf Gypsum granules combined with ranitidine in the treatment of recurrent oral ulcer has significant effect,high safety and low recurrence rate,and it can improve patients pain symptoms and shorten the healing time of ulcers.
作者
石瑾
SHI Jin(Department of Stomatology, Shanxi Provincial Hospital of TCM, Shanxi Province, Taiyuan 030012, China)
出处
《光明中医》
2017年第19期2838-2840,共3页
GUANGMING JOURNAL OF CHINESE MEDICINE
关键词
口疮
复发性口腔溃疡
复方竹叶石膏颗粒
雷尼替丁
中西医结合疗法
Aphtha
Recurrent oral ulcers
Compound Bamboo Leaf Gypsum granules
Ranitidine
Therapy of integrated medicine
