摘要
目的探讨瑞芬太尼-氯胺酮在小儿静脉麻醉中有效性和安全性。方法对西北妇女儿童医院2015年4月～2017年4月收治的80例择期手术患儿的临床资料进行统计分析,依据静脉麻醉方法将这些患儿分为瑞芬太尼-氯胺酮组（40例）和丙泊酚-氯胺酮组（40例）2组,对2组患儿的血流动力学、麻醉药用量、苏醒时间、生活质量、副作用发生情况进行统计分析。结果术中瑞芬太尼-氯胺酮组患儿的HR显著低于丙泊酚-氯胺酮组（P〈0.05）,术后瑞芬太尼-氯胺酮组患儿的麻醉药用量显著少于丙泊酚-氯胺酮组（P〈0.05）,苏醒时间显著短于丙泊酚-氯胺酮组（P〈0.05）,持续哭闹情况、疼痛感评分均显著低于丙泊酚-氯胺酮组（P〈0.05）,生理舒适度评分显著高于丙泊酚-氯胺酮组（P〈0.05）,副作用发生率7.5%（3/40）显著低于丙泊酚-氯胺酮组22.5%（9/40）（P〈0.05）。结论瑞芬太尼-氯胺酮较丙泊酚-氯胺酮在小儿静脉麻醉中有效性和安全性高。
Objective To explore the efficacy and safety of rifentani-ketamine in pediatric intravenous anesthesia.Methods In the northwest women＇s and children＇s hospital between April 2015 and April 2017 clinical data of 80 patients undergoing elective surgery patients in northwest women＇s and children＇s hospital were analyzed,on the basis of these children with intravenous anesthesia method divided into red fentanyl-ketamine group（40 cases） and propofol ketamine group（40 cases） in the two groups,the two groups of children with hemodynamics,drug dosage,wake up of time,quality of life and side effects happening for statistical analysis.Results Intraoperative red fentanyl ketamine group of HR was significantly lower than children with propofol-ketamine group（P〈0.05）,and postoperative fentanyl-children with dosage of anesthetic ketamine group was significantly less than the propofol-ketamine group（P〈0.05）,round time was significantly shorter than the propofol-ketamine group（P〈0.05）,the constant crying,pain scores were significantly lower than propofol-ketamine group（P〈0.05）,physical comfort score was significantly higher than that of propofol-ketamine group（P〈0.05）,the incidence of side effects of 7.5 %（3/40） was significantly lower than propofol-ketamine group 22.5 %（9/40）（P〈0.05）.Conclusion Rifentani-ketamine is more effective and safe in pediatric intravenous anesthesia,and is worth promoting in clinical practice.
出处
《中国生化药物杂志》
CAS
2017年第10期42-44,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
瑞芬太尼-氯胺酮
小儿静脉麻醉
有效性
安全性
rufentani-ketamine
pediatric intravenous anesthesia
effectiveness
security
