摘要
目的分析化学药物与贝伐珠单抗联合治疗晚期胃癌的临床疗效。方法选取浙江省衢化医院60例晚期胃癌患者为研究对象（2016年2月～2017年1月收治）,随机（抽签、就诊序号等方法）将60例晚期胃癌患者分为2组（实验组、对照组,各30例）。对照组常规化疗治疗,实验组在此基础上进行75 mg/kg贝伐珠,2组患者治疗时间均为42 d。比较分析2组患者生活质量及近期疗效等临床指标。结果对照组生活质量评分为（60.30±9.20）显著低于实验组评分为（76.88±10.90）分,具有统计学差异（P〈0.05）。实验组中,恶化患者为3例,稳定患者为7例。对照组中,恶化患者为6例,稳定患者为12例。实验组治疗有效总例数为20例,有效率为66.7%,对照组有效率为40.0%,2组胃癌患者在治疗过程中均未出现严重不良反应,发生率并无显著差异。结论化学药物与贝伐珠单抗联合治疗晚期胃癌的临床疗效较为理想,安全性较高,能够在很大程度上提高患者生活质量,改善临床症状。
Objective To study the clinical efficacy of bevacizumab in combination with chemotherapy in the treatment of advanced gastric cancer.Methods 60 cases of advanced gastric cancer patients as the research object（February 2016 to January 2017）,（random draw,serial number and other treatment methods） 60 cases of advanced lung cancer patients were divided into two groups（experimental group and control group,30 caes）.The control group received routine chemotherapy treatment,the experimental group on the basis of 75 mg/kg bevacizumab,two groups of patients treated for 42 days.Comparative analysis of two groups of patients with quality of life and short-term efficacy and other clinical indicators.Results The quality of life score of the control group was（60.30±9.20）,significantly lower than that of the experimental group,and the score was（76.88±10.90） points,with statistical difference（P〈0.05）.In the experimental group,3 cases were deteriorated,and 7 cases were stable.In the control group,6 cases were worsened,and 12 cases were stable.Available experimental treatment group total effective number of cases to 20 cases,effective rate was 66.7%,the control group was 40.0%,two groups of patients with lung cancer during treatment there were no serious adverse reactions,the incidence rate of no significant difference.Conclusions The clinical curative effect of bevacizumab combined with chemical drugs in the treatment of advanced gastric cancer is ideal,high safety,can improve the quality of life of patients in a large extent,improve the clinical symptoms,has clinical significance.
出处
《中国生化药物杂志》
CAS
2017年第10期237-238,共2页
Chinese Journal of Biochemical Pharmaceutics
关键词
化学药物治疗
贝伐珠单抗
晚期胃癌
临床疗效
chemotherapy
bevacizumab
advanced gastric cancer
clinical curative effect
