摘要
目的分析姑息手术联合FOLFOX辅助化疗对老年中晚期直肠癌患者生存率及生活质量的影响。方法选取永康市第一人民医院2015年5月～2017年5月收治的100例老年中晚期直肠癌患者为研究对象,随机分为对照组和实验组,每组患者各为50例。对照组给予姑息手术治疗;实验组患者给予姑息手术联合FOLFOX辅助化疗。比较分析实验组与对照组患者生存率以及生活质量评分。结果实验组患者的1年生存率为76.0%,对照组患者1年生存率为52.0%。可得,实验组患者的生存率显著高于对照组,差异具有统计学意义（P〈0.05）。治疗后,实验组患者生活质量总评分为（75.2±11.2）分,对照组患者生活质量总评分为（64.2±9.3）分。对照组生活质量评分显著低于实验组,差异具有统计学意义（P〈0.05）。结论姑息手术联合FOLFOX辅助化疗能够显著提高患者的老年中晚期直肠癌患者生存率,提高生活质量。
Objective To investigate the survival rate and effects of life quality of palliative surgery combined with FOLFOX adjuvant chemotherapy on advanced rectal cancer treatment in elderly patients.Methods 100 elderly patients with advanced rectal cancer from May 2015 to May 2017,were randomly divided into the control group and the experimental group,50 patients for each group.The control group was treated with palliative surgery.Patients in the experimental group were given palliative surgery and FOLFOX adjuvant chemotherapy.The survival rate and quality of life score were compared between the experimental and control groups.Results One year survival rate was 76% in the experimental group.One year survival rate was 52% in the control group.The survival rate of the experimental group was significantly higher than that of the control group,with statistical difference（P〈0.05）.After treatment,the total score of quality of life in the experimental group was（75.2±11.2） points,and the total score of QOL in the control group was（64.2±9.3） points.The quality of life score of the control group was lower than that of the experimental group,with statistical difference（P〈0.05）.Conclusion Palliative surgery combined with FOLFOX adjuvant chemotherapy could significantly improve the survival rate of elderly patients with advanced rectal cancer and the quality of life.
出处
《中国生化药物杂志》
CAS
2017年第10期248-249,共2页
Chinese Journal of Biochemical Pharmaceutics
关键词
姑息手术
FOLFOX辅助化疗
老年中晚期直肠癌
生存率
生活质量
palliative surgery
FOLFOX adjuvant chemotherapy
elderly patients with advanced rectal cancer
survival rate
quality of life
