摘要
查阅近10年来国内外针刺治疗高血压病的代谢组学研究文献,分别从临床研究、基础研究两个方面进行分析,重点介绍针刺临床代谢组学研究的特点。研究表明,针刺治疗高血压病有确切疗效,即刻效应显著,长期进行针刺治疗,可稳定血压,相对于药物治疗,针刺治疗安全性高,不良反应少且能有效控制血压,并改善其昼夜节律。目前发现,针刺能调节紊乱代谢,对高血压患者的关键代谢物分子有明显影响,这为探索针刺降压机制提供了有力证据。由于代谢组学包含大量的检测数据,分析过程繁复,所以尚未建立完备的代谢产物数据库,帮助准确快速的找出生物标志物。又因有限的检测技术,要对高血压的关键代谢物分子进行靶向定量分析,并进一步探索其潜在的生物标志物,仍需要努力。
By reviewing metabonomic literature home and abroad on the treatment of hypertension by needling in recent ten years,the article analyzes the metabonomic features of needling from the aspects of clinical study and fundamental researches.It showed needling had definite curative effect on hypertension patients with remarkable immediate effect.Long-time needling can make blood pressure stable.Compared with medicine treatment,needling was safe,with fewer side effects.It can also control blood pressure effectively and improve its diurnal rhythm.It was found needling can regulate metabolism disorder and have significant effect on key metabolites of hypertension patients which provide sound evidence for the depressurization mechanism of needling.Because of the large number of metabonomic data and complicated analysis process,a complete metabonomic product database was still not established to determine its biomarkers.Because of the limitation of detecting techniques,targeted quantitative analysis on key metabolites of hypertension patients was still in its early stage.
出处
《中国疗养医学》
2017年第11期1135-1139,共5页
Chinese Journal of Convalescent Medicine
基金
国家自然科学基金青年基金项目(81403482)
关键词
针刺
高血压
代谢组学
进展
Needling
Hypertension
Metabonomics
Progress
