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克唑替尼与化疗治疗ALK阳性晚期非小细胞肺癌的临床疗效对比分析 被引量:2

Comparative analysis of the clinical efficacy of crizotinib and chemotherapy in the treatment of ALK positive advanced non-small cell lung cancer
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摘要 目的:探讨克唑替尼与化疗治疗ALK阳性晚期非小细胞肺癌的临床效果。方法:收治ALK阳性晚期非小细胞肺癌患者60例,随机分为试验组和对照组。对照组采用化疗治疗,试验组采用克唑替尼治疗,比较两组治疗效果。结果:试验组总有效率和生活质量评分显著高于对照组(P<0.05)。结论:克唑替尼治疗ALK阳性晚期非小细胞肺癌的临床效果显著。 Objective:To explore the clinical efficacy of crizotinib and chemotherapy in the treatment of ALK positive advanced non-small cell lung cancer.Methods:60 patients with ALK positive advanced non-small cell lung cancer were selected.They were randomly divided into the experimental group and the control group.The control group was treated with chemotherapy,and the experimental group was treated with crizotinib.We compared the efficacy of two groups.Results:In the experimental group,the effective rate and the quality of life score were significantly higher than those in the control group(P<0.05).Conclusion:The clinical efficacy of crizotinib in the treatment of ALK positive advanced non-small cell lung cancer was significant.
出处 《中国社区医师》 2017年第31期22-22,24,共2页 Chinese Community Doctors
关键词 非小细胞肺癌 克唑替尼 化疗 Non-small cell lung cancer Crizotinib Chemotherapy
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  • 101ak J. Surgical strategies for metastatic lung cancer[J]. Surg Oncol Clin N Am, 1999,8(2):245-257.
  • 2Yawn BP, Wollan PC, Schroeder C, et al. Temporal and gender-related trends in brain metastases from lung and breast cancer[J]. Minn Med, 2003,86(12):32-37.
  • 3Tasdemiroglu E, Kaya AH, Bek S, et al. Neurologic complications of cancer part 1: Central nervous system metastasis [J]. Neurosurgery Quarterly, 2004,14 (2) :71 - 83.
  • 4Furuse K, Kamimori T, Kawahara M, et al. A pilot study of concurrent whole-brain radiotherapy and chemotherapy combined with cisplatin, vindesine and mitomyein in non-small-cell lung cancer with brainmetastasis[J]. Br J Cancer, 1997,75 (4) :614-618.
  • 5Moscetti L, Nelli F, Felici A, et al. Up-tront chemotherapy and radiation treatment in newly diagnosed nonsmall cell lung cancer with brain metastases: Survey by outcome research network for evaluation of treatment results in oncology [J]. Cancer, 2007,109 (2):274-281.
  • 6Quantin X, Khial F, Reme-Saumon M, et al. Concomitant brain radiotherapy and vinorelbine- ifosfamide-cisplatin chemotherapy in brain metastases of non-small cell lung cancer[J]. Lung Cancer, 1999,26(1): 35-39.
  • 7Gridelli C, Bareschino MA, Schettino C, et al. Erlotinib in non-small cell lung cancer treatment: Current status and future development[J]. Oncologist, 2007,12 (7) :840- 849.
  • 8Broniscer A, Panetta JC, Plasma and cerebrospinal O'Shaughnessy M, et al. fluid pharmacokinetics of erlotinib and its active metabolite osi-420[J]. Clin Cancer Res, 2007,13(5):1511-1515.
  • 9Olmez I, Donahue BR, Butler JS, et al. Clinical outcomes in extracranial tumor sites and unusual toxicities with concurrent whole brain radiation (wbrt) and erlotinib treatment in patients with non-small cell lung cancer (nsclc) with brain metastasis [J]. Lung Cancer, 2010,70 (2): 174-179.
  • 10Katayama T, Shimizu J, Suda K, et al. Efficacy of erlotinib for brain and leptomeningeal metastases in patients with lung adenoearcinoma who showed initial good response to gefitinib [J]. J Thorac Oncol, 2009,4 (11):1415-1419.

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