摘要
目的观察甲羟孕酮片联合甲硝唑和头孢曲松治疗子宫内膜炎的临床疗效及其对相关细胞因子的影响。方法将96例子宫内膜炎患者随机分为试验组与对照组,各48例。对照组给予注射用头孢曲松钠0.5 g,注射用甲硝唑25mg,每天1次,分别静脉滴注,连续治疗14 d。试验组在对照组的基础上给予醋酸甲羟孕酮片2 mg,每天1次,口服,连续服用21 d。2组均连续治疗2个月经周期。比较2组患者的临床疗效、临床症状消退时间、炎症因子变化及药物不良反应发生情况。结果治疗后,试验组和对照组的总有效率分别为95.83%(46/48例),81.25%(39/48例),差异有统计学意义(P<0.05)。治疗后,试验组阴道出血、下腹坠痛、胀痛临床症状消退时间分别为(3.22±0.91),(5.43±2.16),(2.41±1.65)d,对照组分别为(5.18±1.35),(6.56±2.14),(5.26±1.87)d,差异均有统计学意义(均P<0.05)。治疗后,试验组白细胞介素-2(IL-2)、白细胞介素-4(IL-4)及白细胞介素-10(IL^(-1)0)分别为(4.28±1.06),(8.06±1.03),(20.25±4.19)μg·L^(-1),对照组分别为(3.76±0.97),(9.04±0.91),(18.38±3.64)μg·L^(-1),差异均有统计学意义(均P<0.05)。试验组出现头晕1例,困倦2例,药物不良反应发生率为6.25%(3/48例);对照组出现头晕3例,困倦3例,嗜睡4例,药物不良反应发生率为20.83%(10/48例),差异有统计学意义(P<0.05)。结论头孢曲松、甲硝唑联合甲羟孕酮可迅速缓解子宫内膜炎患者各项临床症状,维持炎症因子的平衡,提高临床疗效,且药物不良反应轻微。
Objective To observe the clinical effect of medroxyprogeste- rone combined with ceftriaxone and metronidazole in the treatment of en- dometfitis and its effect on cytokines. Methods Ninety- six patients with endometritis were randomly divided into treatment group and control group, each group 48 cases. Control group was treated with ceftriaxone sodium injection 0. 5 g, metronidazole injection 25 rag, once a day, in- travenous infusion respectively, continuous treatment for 14 d. Treatment group was treated with medroxyprogesterone 2 mg on the basis of control group, once a day, oral, continuous for 21 d. Two groups were treated for 2 menstrual cycles. The clinical efficacy, remission time of clinical symptoms, inflammatory factors and adverse drug reactions in two groups were compared. Results The total effective rates in treatment group and control group were 95.83% （46 cases/48 cases） , 81.25% （39 cases/48 cases）, with significant difference （ P 〈 0. 05 ） . After treatment, thevaginal bleeding time, lower abdominal pain time and bloating time in treatment group were （3.22 ± 0. 91 ）, （5. 43 ±2. 16）, （2. 41 ± 1.65 ）d, had significant difference with those in control group, which were （5. 18± 1.35 ）, （6. 56 ±2. 14）, （5.26 s 1.87）d（P 〈0. 05）. The levels of interleukin -2, interleukin -4, interleukin - 10 in treatment group after treatment were （4. 28 s 1, 06 ）, （ 8.06 ± 1.03 ）, （ 20. 25 ± 4. 19 ） μg·L±（-1）, had significant difference with those in control group, which were （3. 76 s0. 97）, （9. 04 s0. 91 ）, （ 18. 38 s3. 64） μg·L±1 （P 〈0. 05）. There were 1 case of dizziness, 2 cases of drowsiness in treatment group, the incidence of adverse drug reactions was 6. 25% （3 cases/48 cases）. There were 3 cases of dizziness, 3 cases of drowsiness, 4 cases of lethargic, the incidence of adverse drug reactions was 20. 83% （ 10 cases/48 cases ）, with significant difference （ P 〈 0. 05 ）. Conclusion Ceftriaxone, metronidazole combined with medroxyprogesterone in the treatment of patients with endometritis can alleviate the clinical symptoms, main- tain anti -inflammatory/proinflammatory factor balance, improve the clinical effect, and had mild adverse drug reactions.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2017年第20期2002-2004,2008,共4页
The Chinese Journal of Clinical Pharmacology
关键词
子宫内膜炎
甲羟孕酮
甲硝唑
细胞因子
endometritis
medroxyprogesterone
metronidazole
cytokines
