摘要
目的观察氢吗啡酮注射液联合丙泊酚注射液和射频毁损术治疗三叉神经痛的临床疗效及安全性。方法将92例原发性三叉神经痛患者随机分为对照组46例和试验组46例。对照组予以5 mg·kg^(-1)丙泊酚注射液,静脉滴注+射频毁损术;试验组予以氢吗啡酮注射液20 mg·mL^(-1),静脉滴注,15 min后予以5 mg·kg^(-1)丙泊酚注射液,静脉滴注,+射频毁损术。比较2组患者的临床疗效、术中和术后的疼痛视觉模拟量表(VAS)评分,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的优良率分别为91.30%(42例/46例)和73.91%(34例/46例),差异有统计学意义(P<0.05)。试验组术中和术后的VAS评分分别为(3.42±1.12)和(1.13±0.09)分,对照组术中和术后的VAS评分分别为(6.82±0.68)和(3.02±0.21)分,差异均有统计学意义(均P<0.05)。2组患者的药物不良反应以面部感觉丧失、咀嚼肌瘫痪、角膜反射消失和恶心呕吐为主,且试验组和对照组的药物不良反应发生率分别为15.22%和34.81%,差异有统计学意义(P<0.05)。结论氢吗啡酮注射液联合丙泊酚注射液和射频毁损术治疗三叉神经痛的临床疗效确切,其能显著减轻患者术中和术后疼痛,且安全性较高。
Objective To observe the clinical efficacy and safety of hydromorphone hydrochloride injection combined with propofol injection and radiofrequency lesion in the treatment of epileptiform neuralgia. Methods Ninety - two patients of epileptiform neuralgia were divided into control group and treatment group with 46 cases per group. Control group was given 5 mg kg-1 propofol injection, intravenous drip ＋ radiofrequency lesion. Treatment group was given 20 mg · mL-1 hydromorphone hydrochloride injection, intravenous drip, and after 15 min given 5 mg· kg-1 propofol injection, intravenous drip ＋ radiofre- quency lesion. The clinical efficacy, visual analogue scale （VAS） scores and adverse drug reactions were compared between two groups. Results After treatment, excellent rates in treatment and control groups were 91.30% （42 cases/46 cases） and 73.91% （34 cases/46 cases） with significant difference （ P 〈 0. 05 ）. Intraoperative and postoperative, the VAS scores in treatment group were （ 3.42 ± 1.12 ）, （ 1.13 ± 0. 09 ） points, the VAS scores in control group were （6. 82 ±0. 68）, （3. 02 ±0. 21）points, the differences were statistically significant （ all P 〈 0. 05 ）. The adverse drug reactions of two groups were loss of facial sensation, paralysis of mastication, loss of corneal reflection and nausea and vomiting. The incidences of ad- verse drug reactions in treatment and control groups were 15.22% and 34. 81% with significant difference （P 〈0. 05） Conclusion Hydromorphone hydrochloride injection combined with propofol injection and radiofrequency lesion has a definitive clinical efficacy and safety in the treatment of epileptiform neuralgia, which can relieve pain.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2017年第20期2023-2025,共3页
The Chinese Journal of Clinical Pharmacology
基金
宁波市科学技术局基金资助项目(201301C5010132)
