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T细胞介导的炎症反应在心肌纤维化中的“双刃剑”作用 被引量:4

The double-edged sword role of T cell-mediated inflammatory reaction in myocardial fibrosis
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摘要 心肌纤维化涉及到多种复杂的生物学机制。目前,对于免疫介导的心肌纤维化备受关注,而对于心肌损伤时T细胞介导的炎症反应在心肌纤维化中的作用尚存在争议。早期的炎症反应有利于心肌修复,但过度的炎症反应则促进纤维化发生。因此,详尽了解T细胞在心肌纤维化中的作用,有助于通过控制或干预过度的炎症反应来防治心肌纤维化发生,为心脏疾病提供新的治疗方法。 Myocardial fibrosis involves a variety of complex biological mechanisms. At present, the im- mune-mediated myocardial fibrosis has attracted much attention. In the myocardial injury, T cell-mediated in- flammatory reaction in the role of myocardial fibrosis is still controversial. The early inflammatory reaction is conducive to myocardial repair,while excessive inflammation response can contribute to fibrosis. Therefore,un- derstanding the role of T cells in myocardial fibrosis may help us prevent myocardial fibrosis via controlling or intervening the excessive inflammatory response, and may provide new treatment for heart diseases.
作者 石亚男 门素珍 孙孟华 刘巍 Shi Ya'nan Men Suzhen Sun Menghua Lui Wei(Department of Internal Medicine Citical Diseases, the 1 st Affiliated Hospital of Harbin Medical University, Harbin 150010, China)
出处 《国际免疫学杂志》 CAS 2017年第5期553-556,共4页 International Journal of Immunology
基金 国家自然科学基金面上项目(81270310) 哈尔滨医科大学于维汉院士杰出青年基金(301000100005)、黑龙江省教育厅海外学人重点项目(1252HQ013)
关键词 T淋巴细胞 心肌纤维化 心室重构 炎症 T lymphocytes Myocardial, fibrosis Ventricular remodeling Inflammatory
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