摘要
目的:探讨贵阳地区育龄人群血红蛋白A2(HbA_2)和血红蛋白F(HbF)的参考范围。方法:采用毛细管电泳技术,对497例孕妇(正常孕妇组)、180例育龄期男性(正常男性组)和155例育龄期未孕女性(正常女性组)的血红蛋白进行测定,比较各组HbA_2和HbF的检测结果和参考范围。结果:整体HbA_2均值为(2.70±0.21)%,HbF中位数与四分位间距为0(0.3%),参考范围分别为2.3%~3.1%和<0.9%;正常男性组和正常孕妇组的HbA_2的平均值分别为(2.70±0.23)%和(2.70±0.19)%,显著高于正常女性组的(2.63±0.21)%(P<0.01),参考范围分别为2.3%~3.2%、2.3%~3.1%和2.2%~3.0%;正常男性组、正常女性组和正常孕妇组间的HbF分布差异有统计学意义(P<0.01),参考范围分别为<0.5%、<1.1%和<1.0%。结论:贵阳地区育龄人群的HbA_2和HbF数值受到性别及妊娠状态的影响。
Objective： To establish the reference range of HbA2 and Hb F in Guiyang population of reproductive age. Methods： Hemoglobin analysis was performed in 497 pregnant women,180 men of reproductive age and 155 non-pregnant women of reproductive age by using capillary electrophoresis. The value and reference ranges of HbA2 and Hb F of different groups were compared. Results： On the whole,the mean value of HbA2 was（ 2. 70 ± 0. 21） %,the median value and interquartile range of Hb F were 0 and 0. 3%,and the reference ranges of HbA2 and Hb F were 2. 3% ^ 3. 1% less than0. 9% respectively. The mean values of HbA2 of normal men and normal pregnant women were（ 2. 70± 0. 23） % and（ 2. 70 ± 0. 19） % respectively,significantly higher than that of normal female（ 2. 63± 0. 21） %（ P〈0. 01）,with the reference ranges were 2. 3% ^ 3. 2%,2. 3% ^ 3. 1% and 2. 2% ^3. 0% respectively. The distributions of Hb F in normal male,normal female and normal pregnant women had statistical difference（ P〈0. 01）,with the reference ranges less than 0. 5%,1. 1% and1. 0% respectively. Conclusion： The reference ranges of HbA2 and Hb F in Guiyang population of reproductive age have been established. Both gender and pregnancy status have a certain effect on the reference range.
作者
韩文平
王树辉
杨楠楠
徐琴
韩媛媛
黄凌
黄盛文
安邦权
HAN Wenping WANG Shuhui YANG Nannan XU Qin HAN Yuanyuan HUANG Ling HUANG Shengwen AN Bangquan(Department of Medical Laboratory , Guizhou Medical University, Guiyang 550004, Guizhou, China Department of Clinical Laboratory, the People~ Hospital of Guizhou, Guiyang 550002, Guizhou, China)
出处
《贵州医科大学学报》
CAS
2017年第10期1117-1120,共4页
Journal of Guizhou Medical University
基金
国家自然科学基金(81660023)
贵州省科学技术厅基础计划[黔科合人才团队(2015)4019号]
贵阳市科技创新平台计划[筑科合同(20161001)35]
