摘要
目的观察转化生长因子-β1（transforming growth factor-β1,TGF-β1 ）和血管内皮生长因子（vascular endothelial growth factor, VEGF）在乳腺癌组织和癌旁组织中的表达并探讨2者表达的相关性及其与乳腺癌侵袭、转移和预后的内在联系。方法采用免疫组化法检测230例乳腺癌组织芯片及相应癌旁组织中TGF-β1和VEGF的表达，分析其与乳腺癌临床病理参数的关系及2者表达的相关性。结果TGF-β1和VEGF在乳腺癌组织中的阳性率分别为72．6％和68.3％，在癌旁组织中的阳性率分别为21.3％和42．2％。TGF-β1的表达与组织学分级、ER状态和5年是否复发密切相关（P〈0．05），其中ER状态和5年是否复发是TGF—β1蛋白阳性表达的独立预测因子。VEGF的表达与ER状态和5年是否复发密切相关（P〈0．05），其中ER状态是VEGF蛋白阳性表达的独立预测因子。VEGF的表达与TGF—β1的表达呈显著正相关（T=0．419，P〈0．01）。结论乳腺癌组织中TGF-β1和VEGF的表达与肿瘤的侵袭转移和预后密切相关，检测其表达对临床具有一定指导意义。
Objective To observe the expression of transforming growth factor factor-β1 （TGF-β1） and vas cular endothelial growth factor （VEGF） in breast cancer to explore the correlation between each other and their re- lationship with invasion, metastasis and prognosis of breast cancer. Methods Immunohistochemistry was used to detect the expression of TGF-β1 and VEGF in 230 breast cancer tissues and adjacent tissues. The correlation be- tween them and the relationship between their expression and the clinical pathological parameters of breast cancer were analyzed. Results The positive rates of TGF-β1 and VEGF in breast cancer were 72.6% and 68.3%, re- spectively. But in adjacent breast tissues, the positive rate was 21.3% and 42.2% ,respectively.The expression of TGF-β1 was closely related to the histological grade, ER state and 5-year recurrence （P〈0.05）, while ER status and 5-year recurrence were independent predictors of the positive expression of TGF-β1. The expression of VEGF was significantly correlated with ER status and 5-year recurrence （P〈0.05）, while ER status was independent predic- tor of the positive expression of TGF-β1. The expression of VEGF was significantly positively correlated with the expression of TGF-β1 （T=0.419,P〈0.01）. Conclusion The expression of TGF-β1 and VEGF in breast cancer is closely related to the invasion, metastasis and prognosis of breast cancer, which has a certain clinical significance.
出处
《中华内分泌外科杂志》
CAS
2017年第5期364-368,共5页
Chinese Journal of Endocrine Surgery
基金
国家自然科学基金（31600866）
湖北省教育厅科学研究计划指导性项目（B2015350）
武汉市科技计划项目（2017060201010172）
关键词
乳腺癌
转化生长因子-Β1
血管内皮生长因子
转移
复发
Breast cancer
Transforming growth factor factor-β1
Vascular endothelial growth factor
Metastasis
Recurrence
