摘要
骨保护素是属于肿瘤坏死因子超家族成员之一的一种可溶性糖蛋白,近来研究表明骨保护素不仅参与骨代谢,同时与体内能量和糖脂代谢关系密切,且其与动脉粥样硬化及糖脂代谢异常相关的心血管病变、微血管病变联系紧密。骨保护素可能通过调节糖脂代谢和内皮功能、抑制血管钙化、抑制炎症、抑制凋亡等机制参与动脉粥样硬化发生发展过程。
A soluble glycoprotein, termed osteoprotegerin, is a novel member of the tumor necrosis factor receptor superfamily. Recent studies have shown that osteoprotegerin is not only involved in bone metabolism, but also closely re- lated to energy metabolism in vivo, glycolipid metabolism. And it is closely related to atherosclerosis and glycolipid me- tabolism disorders, cardiovascular and microvascular diseases. It is not clear that the mechanism is involved in the occur- rence and progression of atherosclerosis by regulating glucose and lipid metabolism, endothelial function, inhibiting vascular calcification, inhibiting inflammation, inhibiting apoptosis and so on.
作者
许赫
刘长山
窦建新
XU He LIU Chang-Shan DOU Jian-Xin(School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261000, China Department of Endocri- nology, Weifang People＇s Hospital, Weifang, Shandong 261000, China)
出处
《中国动脉硬化杂志》
CAS
北大核心
2017年第9期968-972,共5页
Chinese Journal of Arteriosclerosis
基金
山东省优秀中青年科学家科研奖励基金项目(2014BSA07014)
关键词
骨保护素
动脉粥样硬化
糖脂代谢
Osteoprotegerin
Atherosclerosis
Glycolipid metabolism
