摘要
核因子相关因子2(Nrf2)是调控细胞氧化损伤的关键转录因子,可与抗氧化物元件(antioxidant response element,ARE)结合调控抗氧化物的表达。在氧化应激作用下Nrf2被激活,诱导其下游血红素加氧酶-1(HO-1)等抗氧化酶的表达,通过抗炎、抗氧化和调控细胞凋亡等机制,在肝损伤、脂肪肝、肝纤维化及肝癌等慢性肝病方面具有保护作用。本文通过总结近年来有关Nrf2/HO-1信号通路在慢性肝病中的研究进展,为探索肝病慢性化的发病机制、寻找新的靶点治疗方法提供理论依据。
Nuclear factor-associated factor 2（Nrf2） is a key transcription factor that regulates the oxidative damage and the expression of antioxidants by oxidizing the original（ARE） in cells. Under oxidative stress, Nrf2 is activated and can induce the expression of antioxidant enzymes such as heme oxygenase-1（HO-1） in the downstream tissues. Nrf2 has a protective effect in liver injury, fatty liver, liver fibrosis and liver cancer and other chronic liver disease through its anti-inflammatory, anti-oxidation and regulation of apoptosis and other mechanisms. In this paper, the research progress of Nrf2/HO-1 signaling pathway in chronic liver disease in recent years were summarized to provide the theoretical basis for exploring the pathogenesis of chronic liver disease and finding new target therapy.
作者
张晓倩
杨慧
张晓华
ZHANG Xiao-qian YANG Hui ZHANG Xiao-hua(Department of Infectious Diseases, First Hospital of Shanxi Medical University, Taiyuan 030001, China)
出处
《中国肝脏病杂志（电子版）》
CAS
2017年第3期36-39,共4页
Chinese Journal of Liver Diseases：Electronic Version
基金
山西省卫生计生委科研项目(201601030)
山西省国际合作项目(2014081053-2)
